基线中性粒细胞计数升高与接受放化疗的肌层浸润性膀胱癌患者的较差预后相关。
Elevated Baseline Neutrophil Count Correlates with Worse Outcomes in Patients with Muscle-Invasive Bladder Cancer Treated with Chemoradiation.
作者信息
Meunier Sébastien, Frontczak Alexandre, Balssa Loïc, Blanc Julie, Benhmida Salim, Pernot Mandy, Quivrin Magali, Martin Etienne, Hammoud Yasser, Créhange Gilles, Boustani Jihane
机构信息
Department of Radiation Oncology, Centre Georges François Leclerc, 21000 Dijon, France.
Department of Urology, University Hospital of Besançon, 25000 Besançon, France.
出版信息
Cancers (Basel). 2023 Mar 21;15(6):1886. doi: 10.3390/cancers15061886.
BACKGROUND
The role of inflammation in the development and prognosis of bladder cancer (BC) is now established. We evaluated the significance of neutrophil-to-lymphocyte ratio (NLR) and neutrophil count (PNN) in patients with localized BC treated with chemoradiation.
METHODS
Clinical characteristics and baseline biological data were retrospectively collected. We tested the association between NLR, PNN, and overall survival (OS) and progression-free survival (PFS).
RESULTS
One hundred and ninety-four patients were included. Median PNN was 4000.0/mm [1500.0-16,858.0] and median NLR was 2.6 [0.6-19.2]. In patients with NLR > 2.6, median OS and PFS were lower (OS: 25.5 vs. 58.4 months, = 0.02; PFS: 14.1 vs. 26.7 months, = 0.07). Patients with PNN > 4000/mm had significantly lower OS (21.8 vs. 70.1 months, < 0.001) and PFS (13.7 vs. 38.8 months, < 0.001). Contrary to NLR, PNN > 4000/mm was associated with shorter OS and PFS in multivariate analysis.
CONCLUSIONS
Elevated PNN at baseline was associated with worse OS and PFS. NLR was not an independent prognostic factor.
背景
炎症在膀胱癌（BC）发生发展及预后中的作用现已明确。我们评估了中性粒细胞与淋巴细胞比值（NLR）和中性粒细胞计数（PNN）在接受放化疗的局限性BC患者中的意义。
方法
回顾性收集临床特征和基线生物学数据。我们检测了NLR、PNN与总生存期（OS）和无进展生存期（PFS）之间的关联。
结果
纳入194例患者。PNN中位数为4000.0/mm[1500.0 - 16,858.0]，NLR中位数为2.6[0.6 - 19.2]。NLR>2.6的患者，OS和PFS中位数较低（OS：25.5个月对58.4个月，P = 0.02；PFS：14.1个月对26.7个月，P = 0.07）。PNN>4000/mm的患者OS（21.8个月对70.1个月，P<0.001）和PFS（13.7个月对38.8个月，P<0.001）显著更低。与NLR相反，多因素分析显示PNN>4000/mm与较短的OS和PFS相关。
结论
基线时PNN升高与较差的OS和PFS相关。NLR不是独立的预后因素。
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