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关于法医 DNA 混合物复合似然比的研究。

An Investigation into Compound Likelihood Ratios for Forensic DNA Mixtures.

机构信息

Institute of Environmental Science and Research Limited, Private Bag 92012, Auckland, New Zealand.

Alabama Department of Forensic Sciences, 1 Forensic Drive, Mobile, AL 36617, USA.

出版信息

Genes (Basel). 2023 Mar 14;14(3):714. doi: 10.3390/genes14030714.

Abstract

Simple propositions are defined as those with one POI and the remaining contributors unknown under and all unknown contributors under . Conditional propositions are defined as those with one POI, one or more assumed contributors, and the remaining contributors (if any) unknown under , and the assumed contributor(s) and N unknown contributors under . In this study, compound propositions are those with multiple POI and the remaining contributors unknown under and all unknown contributors under Ha. We study the performance of these three proposition sets on thirty-two samples (two laboratories × four NOCs × four mixtures) consisting of four mixtures, each with N = 2, N = 3, N = 4, and N = 5 contributors using the probabilistic genotyping software, STRmix™. In this study, it was found that conditional propositions have a much higher ability to differentiate true from false donors than simple propositions. Compound propositions can misstate the weight of evidence given the propositions strongly in either direction.

摘要

简单命题被定义为在 和 下,只有一个 POI 和其余未知贡献者的命题,以及在 下所有未知贡献者的命题。条件命题被定义为在 和 下,有一个 POI、一个或多个假定贡献者和其余未知贡献者(如果有)的命题,以及假定贡献者和 N 个未知贡献者的命题。在本研究中,复合命题是指在 和 下有多个 POI 和其余未知贡献者的命题。我们使用概率基因分型软件 STRmix™,研究了这三个命题集在由四个混合物组成的三十二个样本(两个实验室×四个 NOCs×四个混合物)上的性能,每个混合物的 N = 2、N = 3、N = 4 和 N = 5 个贡献者。在本研究中,发现条件命题在区分真实和虚假供体方面的能力远高于简单命题。复合命题可以根据命题的强烈方向错误地陈述证据的权重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/216da3125e6a/genes-14-00714-g001.jpg

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