• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

关于法医 DNA 混合物复合似然比的研究。

An Investigation into Compound Likelihood Ratios for Forensic DNA Mixtures.

机构信息

Institute of Environmental Science and Research Limited, Private Bag 92012, Auckland, New Zealand.

Alabama Department of Forensic Sciences, 1 Forensic Drive, Mobile, AL 36617, USA.

出版信息

Genes (Basel). 2023 Mar 14;14(3):714. doi: 10.3390/genes14030714.

DOI:10.3390/genes14030714
PMID:36980986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10048689/
Abstract

Simple propositions are defined as those with one POI and the remaining contributors unknown under and all unknown contributors under . Conditional propositions are defined as those with one POI, one or more assumed contributors, and the remaining contributors (if any) unknown under , and the assumed contributor(s) and N unknown contributors under . In this study, compound propositions are those with multiple POI and the remaining contributors unknown under and all unknown contributors under Ha. We study the performance of these three proposition sets on thirty-two samples (two laboratories × four NOCs × four mixtures) consisting of four mixtures, each with N = 2, N = 3, N = 4, and N = 5 contributors using the probabilistic genotyping software, STRmix™. In this study, it was found that conditional propositions have a much higher ability to differentiate true from false donors than simple propositions. Compound propositions can misstate the weight of evidence given the propositions strongly in either direction.

摘要

简单命题被定义为在 和 下,只有一个 POI 和其余未知贡献者的命题,以及在 下所有未知贡献者的命题。条件命题被定义为在 和 下,有一个 POI、一个或多个假定贡献者和其余未知贡献者(如果有)的命题,以及假定贡献者和 N 个未知贡献者的命题。在本研究中,复合命题是指在 和 下有多个 POI 和其余未知贡献者的命题。我们使用概率基因分型软件 STRmix™,研究了这三个命题集在由四个混合物组成的三十二个样本(两个实验室×四个 NOCs×四个混合物)上的性能,每个混合物的 N = 2、N = 3、N = 4 和 N = 5 个贡献者。在本研究中,发现条件命题在区分真实和虚假供体方面的能力远高于简单命题。复合命题可以根据命题的强烈方向错误地陈述证据的权重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/b52b8af04eac/genes-14-00714-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/216da3125e6a/genes-14-00714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/4ce82288226d/genes-14-00714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/e9ff2cbd69d5/genes-14-00714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/4ed310594b73/genes-14-00714-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/b52b8af04eac/genes-14-00714-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/216da3125e6a/genes-14-00714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/4ce82288226d/genes-14-00714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/e9ff2cbd69d5/genes-14-00714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/4ed310594b73/genes-14-00714-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe43/10048689/b52b8af04eac/genes-14-00714-g005.jpg

相似文献

1
An Investigation into Compound Likelihood Ratios for Forensic DNA Mixtures.关于法医 DNA 混合物复合似然比的研究。
Genes (Basel). 2023 Mar 14;14(3):714. doi: 10.3390/genes14030714.
2
Comparing multiple POI to DNA mixtures.比较多个 POI 与 DNA 混合物。
Forensic Sci Int Genet. 2021 May;52:102481. doi: 10.1016/j.fsigen.2021.102481. Epub 2021 Feb 9.
3
Internal validation of STRmix™ for the interpretation of single source and mixed DNA profiles.用于单源和混合DNA图谱解读的STRmix™内部验证
Forensic Sci Int Genet. 2017 Jul;29:126-144. doi: 10.1016/j.fsigen.2017.04.004. Epub 2017 Apr 5.
4
Internal Validation of MaSTR™ Probabilistic Genotyping Software for the Interpretation of 2-5 Person Mixed DNA Profiles.MaSTR™ 概率基因分型软件在 2-5 人混合 DNA 谱分析解读中的内部验证。
Genes (Basel). 2022 Aug 11;13(8):1429. doi: 10.3390/genes13081429.
5
An inter-laboratory comparison of probabilistic genotyping parameters and evaluation of performance on DNA mixtures from different laboratories.不同实验室概率基因分型参数的实验室间比较及对不同来源 DNA 混合样本检测性能的评估。
Forensic Sci Int Genet. 2024 Jul;71:103046. doi: 10.1016/j.fsigen.2024.103046. Epub 2024 Apr 3.
6
Addressing uncertain assumptions in DNA evidence evaluation.解决 DNA 证据评估中的不确定假设。
Forensic Sci Int Genet. 2023 Sep;66:102913. doi: 10.1016/j.fsigen.2023.102913. Epub 2023 Jul 11.
7
The Probabilistic Genotyping Software STRmix: Utility and Evidence for its Validity.概率基因分型软件STRmix:其实用性及其有效性的证据
J Forensic Sci. 2019 Mar;64(2):393-405. doi: 10.1111/1556-4029.13898. Epub 2018 Aug 21.
8
The efficacy of DNA mixture to mixture matching.DNA 混合与混合匹配的功效。
Forensic Sci Int Genet. 2019 Jul;41:64-71. doi: 10.1016/j.fsigen.2019.02.020. Epub 2019 Mar 30.
9
When evaluating DNA evidence within a likelihood ratio framework, should the propositions be exhaustive?在似然比框架内评估 DNA 证据时,命题是否应该详尽无遗?
Forensic Sci Int Genet. 2021 Jan;50:102406. doi: 10.1016/j.fsigen.2020.102406. Epub 2020 Oct 22.
10
A mixed DNA profile controversy revisited.重新审视混合DNA图谱争议。
J Forensic Sci. 2022 Jan;67(1):128-135. doi: 10.1111/1556-4029.14912. Epub 2021 Oct 14.

本文引用的文献

1
Compound and Conditioned Likelihood Ratio Behavior within a Probabilistic Genotyping Context.在概率基因分型背景下的复合和条件似然比行为。
Genes (Basel). 2022 Nov 4;13(11):2031. doi: 10.3390/genes13112031.
2
Exploring likelihood ratios assigned for siblings of the true mixture contributor as an alternate contributor.将真正混合样本贡献者的兄弟姐妹指定为替代贡献者来探索似然比。
J Forensic Sci. 2022 May;67(3):1167-1175. doi: 10.1111/1556-4029.15020. Epub 2022 Feb 24.
3
The comparison of DNA mixture profiles with multiple persons of interest.
与多个嫌疑人的 DNA 混合谱进行比较。
Forensic Sci Int Genet. 2022 Jan;56:102592. doi: 10.1016/j.fsigen.2021.102592. Epub 2021 Sep 10.
4
When evaluating DNA evidence within a likelihood ratio framework, should the propositions be exhaustive?在似然比框架内评估 DNA 证据时,命题是否应该详尽无遗?
Forensic Sci Int Genet. 2021 Jan;50:102406. doi: 10.1016/j.fsigen.2020.102406. Epub 2020 Oct 22.
5
A review of likelihood ratios in forensic science based on a critique of Stiffelman "No longer the Gold standard: Probabilistic genotyping is changing the nature of DNA evidence in criminal trials".基于对斯蒂夫曼的“不再是黄金标准:概率基因分型正在改变刑事审判中 DNA 证据的性质”的批判,对法庭科学中似然比的综述。
Forensic Sci Int. 2020 May;310:110251. doi: 10.1016/j.forsciint.2020.110251. Epub 2020 Mar 13.
6
DNA commission of the International society for forensic genetics: Assessing the value of forensic biological evidence - Guidelines highlighting the importance of propositions: Part I: evaluation of DNA profiling comparisons given (sub-) source propositions.国际法医遗传学会 DNA 委员会:评估法医生物证据的价值——强调命题重要性的指南:第一部分:评估给定(子)来源命题的 DNA 图谱比较。
Forensic Sci Int Genet. 2018 Sep;36:189-202. doi: 10.1016/j.fsigen.2018.07.003. Epub 2018 Jul 8.
7
Developmental validation of STRmix™, expert software for the interpretation of forensic DNA profiles.STRmix™的发育验证,用于法医DNA图谱解释的专家软件。
Forensic Sci Int Genet. 2016 Jul;23:226-239. doi: 10.1016/j.fsigen.2016.05.007. Epub 2016 May 12.
8
On the use of the likelihood ratio for forensic evaluation: response to Fenton et al.关于似然比在法医评估中的应用:对芬顿等人的回应
Sci Justice. 2014 Jul;54(4):316-8. doi: 10.1016/j.scijus.2014.04.001. Epub 2014 May 2.
9
Helping formulate propositions in forensic DNA analysis.协助制定法医DNA分析中的命题。
Sci Justice. 2014 Jul;54(4):258-61. doi: 10.1016/j.scijus.2014.02.007. Epub 2014 Mar 20.
10
Using continuous DNA interpretation methods to revisit likelihood ratio behaviour.使用连续DNA解释方法重新审视似然比行为。
Forensic Sci Int Genet. 2014 Jul;11:144-53. doi: 10.1016/j.fsigen.2014.03.008. Epub 2014 Mar 25.