Diwan B A, Rice J M, Ward J M
Carcinogenesis. 1986 May;7(5):789-94. doi: 10.1093/carcin/7.5.789.
The widely used benzodiazepine tranquilizers diazepam and oxazepam promoted development of hepatocellular hyperplastic foci and hepatocellular neoplasms (adenomas and carcinomas) when they were fed in diet to male B6C3F1 mice after initiation by N-nitrosodiethylamine. Diazepam was more effective than oxazepam and its effect was proportionate to dose. Both diazepam and oxazepam induced hepatomegaly, cytochrome P-450 and cytochrome P-450-dependent aminopyrine N-demethylase activity in hepatocytes, effects similar to those produced by a well-known rodent liver tumor promoter, phenobarbital. In view of the importance and widespread use of this class of compounds, more work is warranted to examine their effects on tumor development in different mammalian species.
在经N-亚硝基二乙胺启动后，将广泛使用的苯二氮䓬类镇静剂地西泮和奥沙西泮添加到雄性B6C3F1小鼠的饮食中时，会促进肝细胞增生灶和肝细胞肿瘤（腺瘤和癌）的发展。地西泮比奥沙西泮更有效，且其作用与剂量成正比。地西泮和奥沙西泮均会引起肝肿大，诱导肝细胞中的细胞色素P-450和细胞色素P-450依赖性氨基比林N-脱甲基酶活性，这些作用与一种著名的啮齿动物肝脏肿瘤促进剂苯巴比妥所产生的作用相似。鉴于这类化合物的重要性和广泛应用，有必要开展更多研究来考察它们对不同哺乳动物物种肿瘤发展的影响。
