Occupation, Environment and Safety, School of Population Health, Curtin University, Perth, WA 6845, Australia.
Respiratory Environmental Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Perth, WA 6009, Australia.
Int J Mol Sci. 2023 Mar 7;24(6):5130. doi: 10.3390/ijms24065130.
Biodiesel, which can be made from a variety of natural oils, is currently promoted as a sustainable, healthier replacement for commercial mineral diesel despite little experimental data supporting this. The aim of our research was to investigate the health impacts of exposure to exhaust generated by the combustion of diesel and two different biodiesels. Male BALB/c mice ( = 24 per group) were exposed for 2 h/day for 8 days to diluted exhaust from a diesel engine running on ultra-low sulfur diesel (ULSD) or Tallow or Canola biodiesel, with room air exposures used as control. A variety of respiratory-related end-point measurements were assessed, including lung function, responsiveness to methacholine, airway inflammation and cytokine response, and airway morphometry. Exposure to Tallow biodiesel exhaust resulted in the most significant health impacts compared to Air controls, including increased airway hyperresponsiveness and airway inflammation. In contrast, exposure to Canola biodiesel exhaust resulted in fewer negative health effects. Exposure to ULSD resulted in health impacts between those of the two biodiesels. The health effects of biodiesel exhaust exposure vary depending on the feedstock used to make the fuel.
生物柴油可以由多种天然油脂制成，目前被宣传为商业矿物柴油的可持续、更健康的替代品，尽管几乎没有实验数据支持这一点。我们的研究旨在调查暴露于燃烧柴油和两种不同生物柴油产生的废气对健康的影响。雄性 BALB/c 小鼠（每组 24 只）每天暴露于超低硫柴油（ULSD）或牛脂或菜籽油生物柴油发动机稀释的废气中 2 小时，以空气暴露作为对照。评估了各种与呼吸相关的终点测量，包括肺功能、对乙酰甲胆碱的反应性、气道炎症和细胞因子反应以及气道形态计量学。与空气对照相比，暴露于牛脂生物柴油废气导致最显著的健康影响，包括气道高反应性和气道炎症增加。相比之下，暴露于菜籽油生物柴油废气导致的健康负面影响较少。暴露于 ULSD 导致的健康影响介于两种生物柴油之间。生物柴油废气暴露的健康影响取决于用于制造燃料的原料。
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