Nesbit Michael, Ko Colleen Kah Ling, Mamo John C L, Lam Virginie, Landwehr Katherine R, Larcombe Alexander N, Takechi Ryu
Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
School of Population Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia.
Front Neurosci. 2024 Sep 13;18:1440118. doi: 10.3389/fnins.2024.1440118. eCollection 2024.
Emerging data suggest that air pollution is a persistent source of neuroinflammation, reactive oxygen species (ROS), and neuropathology that contributes to central nervous system (CNS) disorders. Previous research using animal models has shown that exposure to diesel exhaust causes considerable disruption of the blood-brain barrier (BBB), leading to marked neuroinflammation. However, the effects of biodiesel exhaust on cerebrovascular integrity and neuroinflammation have not been explored previously. Therefore, in this study, 8-week-old BALB/c mice were exposed to biodiesel exhaust (derived from canola biodiesel or tallow biodiesel) and compared with control mice that were exposed to air or mineral diesel exhaust. Consistently with previous findings, the integrity of the BBB was significantly disrupted by exposure to mineral diesel exhaust. Tallow and canola biodiesel exhaust exposure resulted in no BBB disruption. Moreover, both tallow and canola biodiesels significantly attenuated oxidative stress in the brain. The data collectively suggest that biodiesel exhaust may exert significantly less detrimental effects on brain function, compared to mineral diesel.
新出现的数据表明，空气污染是神经炎症、活性氧（ROS）和神经病理学的持续来源，会导致中枢神经系统（CNS）疾病。先前使用动物模型的研究表明，接触柴油废气会导致血脑屏障（BBB）受到相当大的破坏，从而引发明显的神经炎症。然而，生物柴油废气对脑血管完整性和神经炎症的影响此前尚未得到研究。因此，在本研究中，将8周龄的BALB/c小鼠暴露于生物柴油废气（源自油菜籽生物柴油或牛脂生物柴油）中，并与暴露于空气或矿物柴油废气的对照小鼠进行比较。与先前的研究结果一致，暴露于矿物柴油废气会显著破坏血脑屏障的完整性。而暴露于牛脂和油菜籽生物柴油废气中则不会导致血脑屏障被破坏。此外，牛脂和油菜籽生物柴油均能显著减轻大脑中的氧化应激。这些数据共同表明，与矿物柴油相比，生物柴油废气对脑功能的有害影响可能要小得多。
