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芦荟大黄素对脑卒中后抑郁模型大鼠脑水通道蛋白表达及神经营养因子分泌的影响。

Effects of Aloe-Emodin on the Expression of Brain Aquaporins and Secretion of Neurotrophic Factors in a Rat Model of Post-Stroke Depression.

机构信息

College of Life Science and Engineering, Southwest Jiao tong University, Chengdu 610031, China.

出版信息

Int J Mol Sci. 2023 Mar 8;24(6):5206. doi: 10.3390/ijms24065206.

DOI:10.3390/ijms24065206
PMID:36982280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10048947/
Abstract

Post-stroke depression (PSD) is a common complication of stroke that can damage patients' brains. More and more studies have been conducted on PSD in recent years, but the exact mechanism is still not understood. Currently, animal models provide an alternative approach to better understand the pathophysiology of PSD and may also pave the way for the discovery of new treatments for depression. This study investigated the therapeutic effect and mechanism of aloe-emodin (AE) on PSD rats. Previous studies have shown that AE positively affects PSD in rats by improving depression, increasing their activities and curiosities, enhancing the number of neurons, and ameliorating damage to brain tissue. Meanwhile, AE could up-regulate the expression of brain-derived neurotrophic factor (BDNF) and neurotrophic 3 (NTF3), but it could also down-regulate the expression of aquaporins (AQP3, AQP4, and AQP5), glial fibrillary acidic protein (GFAP), and transient receptor potential vanilloid 4 (TRPV4), which is helpful in maintaining homeostasis and alleviating encephaledema. AE may be a prospective solution in the future for the treatment of PSD patients.

摘要

脑卒中后抑郁（PSD）是脑卒中的一种常见并发症，可损害患者的大脑。近年来，越来越多的研究对 PSD 进行了研究，但确切的机制仍不清楚。目前，动物模型提供了一种替代方法，可以更好地了解 PSD 的病理生理学，也可能为发现新的抑郁症治疗方法铺平道路。本研究探讨了大黄素（AE）对 PSD 大鼠的治疗作用及其机制。先前的研究表明，AE 通过改善抑郁、提高大鼠的活动和好奇心、增加神经元数量以及改善脑组织损伤，对 PSD 大鼠产生积极影响。同时，AE 可以上调脑源性神经营养因子（BDNF）和神经营养因子 3（NTF3）的表达，但也可以下调水通道蛋白（AQP3、AQP4 和 AQP5）、神经胶质纤维酸性蛋白（GFAP）和瞬时受体电位香草醛 4（TRPV4）的表达，这有助于维持内环境平衡和减轻脑水肿。AE 可能是未来治疗 PSD 患者的一种有前途的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/59886f75e871/ijms-24-05206-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/8e4b1641556f/ijms-24-05206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/d90aa36a2f73/ijms-24-05206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/064b2fa8104b/ijms-24-05206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/bd9d5ba6ebe7/ijms-24-05206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/ba1868c142be/ijms-24-05206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/59886f75e871/ijms-24-05206-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/8e4b1641556f/ijms-24-05206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/d90aa36a2f73/ijms-24-05206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/064b2fa8104b/ijms-24-05206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/bd9d5ba6ebe7/ijms-24-05206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/ba1868c142be/ijms-24-05206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f66/10048947/59886f75e871/ijms-24-05206-g006.jpg

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Effects of Aloe-Emodin on the Expression of Brain Aquaporins and Secretion of Neurotrophic Factors in a Rat Model of Post-Stroke Depression.

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引用本文的文献

[1]
Post stroke depression: pathogenesis and molecular mechanisms of natural product-based interventions.

Front Pharmacol. 2025-5-19

[2]
Pharmacology, medical uses, and clinical translational challenges of Saikosaponin A: A review.

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[3]
Inflammatory Pathogenesis of Post-stroke Depression.

Aging Dis. 2024-2-9

[4]
Inhibition of SK Channels in VTA Affects Dopaminergic Neurons to Improve the Depression-Like Behaviors of Post-Stroke Depression Rats.

Neuropsychiatr Dis Treat. 2023-10-9

本文引用的文献

[1]
Rho-Kinase/ROCK Phosphorylates PSD-93 Downstream of NMDARs to Orchestrate Synaptic Plasticity.

Int J Mol Sci. 2022-12-26

[2]
AQP4, Astrogenesis, and Hydrocephalus: A New Neurological Perspective.

Int J Mol Sci. 2022-9-9

[3]
proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model.

Transl Psychiatry. 2021-11-10

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TRPing on Cell Swelling - TRPV4 Senses It.

Front Immunol. 2021

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Biomolecules. 2021-9-14

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Emodin - A natural anthraquinone derivative with diverse pharmacological activities.

Phytochemistry. 2021-10

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Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.

Food Funct. 2021-9-7

[8]
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.

Brain Res Bull. 2021-8

[9]
Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.

FASEB J. 2021-5

[10]
Rosmarinic acid protects rats against post-stroke depression after transient focal cerebral ischemic injury through enhancing antioxidant response.

Brain Res. 2021-4-15

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