Dascalu Joel, Zaaroura Hiba, Renert-Yuval Yael, Khamaysi Ziyad, Avitan-Hersh Emily, Friedland Rivka
Department of Dermatology, Rambam Health Care Campus, Haifa 3525408, Israel.
Pediatric Dermatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva 4920235, Israel.
J Fungi (Basel). 2023 Mar 17;9(3):366. doi: 10.3390/jof9030366.
Pediatric tinea capitis displays a wide range of prevalence, with significant variability among populations. We retrospectively extracted the medical records of 456 pediatric patients diagnosed with tinea capitis during the years 2010-2021, from the dermatology outpatient clinics in two tertiary medical centers. Three species were isolated in 90% of patients: , , and While presented a six-fold increase in incidence during the years 2019-2021, maintained stable incidence rates. Furthermore, terbinafine was the most efficient antifungal agent against , achieving complete clinical clearance in 95% of patients, as compared to fluconazole (68%) and griseofulvin (38%) ( < 0.001). The mycological cure was recorded in 61/90 (68%) of patients with available data, at an average of 10 weeks. For patients with , griseofulvin and fluconazole were equally efficient (73% and 66%, respectively) ( = 0.44). Kerion was described in 36% and 14% of patients with and , respectively, ( < 0.001). In conclusion, since 2019, there has been a significant increase in the prevalence of , establishing this pathogen as the most common cause for tinea capitis in our population. Our data suggest that terbinafine is effective and presents high cure rates for tinea capitis in the pediatric population.
儿童头癣的患病率范围广泛，不同人群之间存在显著差异。我们回顾性提取了2010年至2021年期间在两家三级医疗中心皮肤科门诊被诊断为头癣的456例儿科患者的病历。90%的患者分离出三种菌种： 、 和 。虽然 在2019年至2021年期间发病率增加了六倍，但 发病率保持稳定。此外，特比萘芬是针对 最有效的抗真菌药物，95%的患者实现了临床完全清除，相比之下氟康唑为68%，灰黄霉素为38%（ < 0.001）。在有可用数据的90例患者中，61例（68%）实现了真菌学治愈，平均时间为10周。对于 患者，灰黄霉素和氟康唑同样有效（分别为73%和66%）（ = 0.44）。分别有36%和14%的 患者和 患者出现脓癣（ < 0.001）。总之，自2019年以来， 的患病率显著增加，使其成为我们人群中头癣最常见的病因。我们的数据表明，特比萘芬对儿科人群头癣有效且治愈率高。
