Szakács Zsolt, Farkas Nelli, Nagy Enikő, Bencs Réka, Vereczkei Zsófia, Bajor Judit
First Department of Medicine, Medical School, University of Pécs, Ifjúság Str 13., H-7624 Pécs, Hungary.
Institute for Bioanalysis, Medical School, University of Pécs, Szigeti Str 12, H-7624 Pécs, Hungary.
J Pers Med. 2023 Mar 8;13(3):487. doi: 10.3390/jpm13030487.
International trends indicate that celiac disease (CeD) is becoming more common, while the clinical presentation of CeD tends to change. We aimed to investigate factors associated with the clinical presentation of CeD. We reviewed all CeD cases diagnosed at our tertiary center, University of Pécs (Hungary), between 1992 and 2019. We collected data of verified CeD patients on clinical presentations (classified by the Oslo Classification), the age at and calendar year of diagnosis, and sex, serology and histology at diagnosis. To assess the associations of baseline variables with clinical presentations, we applied univariate and multivariate (binary logistic regression) statistics. A total of 738 CeD patients were eligible for inclusion. In the univariate analysis, patients with classical CeD were more common in the latest calendar period ( < 0.001) and tended to be older ( = 0.056), but we failed to observe a significant association between the clinical presentation and sex, serology or histology at diagnosis. In the multivariate analysis, only age at diagnosis and calendar year were independently associated with clinical presentations (OR = 1.02, CI: 1.01-1.04 and OR = 0.93, CI: 0.89-0.98, respectively). Our findings confirmed that classical CeD is independently associated with age at diagnosis and calendar year of diagnosis of CeD, whereas other parameters were not significantly associated with clinical presentations.
国际趋势表明，乳糜泻（CeD）正变得越来越普遍，而CeD的临床表现也趋于变化。我们旨在调查与CeD临床表现相关的因素。我们回顾了1992年至2019年期间在我们位于匈牙利佩奇大学的三级中心确诊的所有CeD病例。我们收集了经证实的CeD患者的临床表现（按奥斯陆分类法分类）、诊断时的年龄和年份以及诊断时的性别、血清学和组织学数据。为了评估基线变量与临床表现之间的关联，我们应用了单变量和多变量（二元逻辑回归）统计分析。共有738例CeD患者符合纳入标准。在单变量分析中，典型CeD患者在最近一个日历期更为常见（<0.001），且往往年龄较大（=0.056），但我们未观察到临床表现与诊断时的性别、血清学或组织学之间存在显著关联。在多变量分析中，只有诊断时的年龄和日历年份与临床表现独立相关（OR分别为1.02，CI：1.01 - 1.04和OR为0.93，CI：0.89 - 0.98）。我们的研究结果证实，典型CeD与CeD的诊断年龄和诊断日历年份独立相关，而其他参数与临床表现无显著关联。
