Bajor Judit, Vereczkei Zsófia, Bencs Réka, Nagy Enikő, Peresztegi Míra Zsófia, Hegedűs Ivett, Farkas Nelli, Tárnok András, Szigeti Nóra, Szakács Zsolt
First Department of Medicine, Medical School, University of Pécs, Ifjúság Str. 13, H-7624 Pécs, Hungary.
Institute for Translational Medicine, Medical School, University of Pécs, Szigeti Str. 12, H-7624 Pécs, Hungary.
J Pers Med. 2025 Jan 29;15(2):55. doi: 10.3390/jpm15020055.
The clinical presentation of coeliac disease (CD) is various and may influence disease course. We aimed to investigate the associations of clinical presentation with comorbidities and disease complications in a cohort of Hungarian coeliac patients. In this retrospective study, data of consecutive CD patients were analysed. Clinical presentation (classical vs. non-classical), extraintestinal manifestations and comorbidities (anaemia, metabolic bone disease, dermatitis herpetiformis, IgA deficiency, chromosomal abnormalities, autoimmune diseases and malignancy) were assessed. Student's -test (for age at diagnosis) and the Chi-squared test or Fisher's exact test (for categorical variables) were applied as analyses. A total of 738 patients were included. In classical vs. non-classical comparisons, classical presentation was significantly associated with metabolic bone disease (59 vs. 36%, respectively, < 0.001), anaemia (47 vs. 38%, respectively, = 0.027) and malignancy (6 vs. 2%, respectively, = 0.006); however, autoimmune diseases and dermatitis herpetiformis were more common with non-classical presentation (23 vs. 31%, = 0.02, and 5 vs. 16%, = 0.014, respectively). Our findings confirm that clinical presentation is associated with certain comorbidities and complications in CD. More personalised follow-up may be recommended based on clinical presentation.
乳糜泻（CD）的临床表现多种多样，且可能影响疾病进程。我们旨在调查一组匈牙利乳糜泻患者的临床表现与合并症及疾病并发症之间的关联。在这项回顾性研究中，对连续的CD患者数据进行了分析。评估了临床表现（典型与非典型）、肠外表现及合并症（贫血、代谢性骨病、疱疹样皮炎、IgA缺乏、染色体异常、自身免疫性疾病和恶性肿瘤）。采用学生t检验（用于诊断时的年龄）和卡方检验或Fisher精确检验（用于分类变量）进行分析。共纳入738例患者。在典型与非典型表现的比较中，典型表现与代谢性骨病（分别为59%和36%，<0.001）、贫血（分别为47%和38%，=0.027）及恶性肿瘤（分别为6%和2%，=0.006）显著相关；然而，自身免疫性疾病和疱疹样皮炎在非典型表现中更为常见（分别为23%和31%，=0.02，以及5%和16%，=0.014）。我们的研究结果证实，乳糜泻的临床表现与某些合并症及并发症相关。基于临床表现，可能建议进行更具个性化的随访。
