Montanhini Priscilla, Antunes Bruno P, Pestilho Julie Francine Cerutti, Galia Carlos Roberto, Guedes Alex, Becker Ricardo Gehrke
Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos, 2350, Porto Alegre 90035-903, RS, Brazil.
Hospital Moinhos de Vento (HMV), Rua Ramiro Barcelos, 910, Porto Alegre 90035-000, RS, Brazil.
Life (Basel). 2023 Mar 15;13(3):789. doi: 10.3390/life13030789.
We retrospectively reviewed 28 patients (15 women and 13 men) with benign bone tumors or pseudotumors treated with curettage and filling with freeze-dried bovine bone graft Orthogen (Baumer S/A, São Paulo, Brazil). The aim of the study was to evaluate the rate of incorporation of Orthogen into the host bone, as well as to describe the outcomes of bone healing (quality, time, and complications). General characteristics, tumor volume, size, site, complications, percent filled, and healing quality at 6 and 12 months were assessed through radiographs. Mean patient age was 20.5 (range 4.7-75.1) years. The most common lesion type was simple bone cyst (12/28), and the most common sites were the tibia (7/28) and humerus (7/28). There were no postoperative pathologic fractures. Two cases (7.1%) of serous fluid leakage through the wound occurred. Mean cavity volume was 20.1 (range 2.7-101.4) cm. At 6 and 12 months, 75% and 77.8% of cavities, respectively, showed complete bone healing. At 12 months, 81% of cavities filled >90% with graft showed complete bone healing vs. only 19% of those filled <90%. Filling with bovine bone graft resulted in few complications and excellent healing after curettage of benign bone tumors or pseudotumors. Complete healing occurred in most cases by 12 months. Cavities with a higher percentage of filling had a higher rate of complete radiographic incorporation.
我们回顾性分析了28例接受刮除术并填充冻干牛骨移植材料Orthogen（巴西圣保罗的Baumer S/A公司生产）治疗的良性骨肿瘤或假肿瘤患者（15例女性和13例男性）。本研究的目的是评估Orthogen与宿主骨的融合率，并描述骨愈合的结果（质量、时间和并发症）。通过X线片评估患者的一般特征、肿瘤体积、大小、部位、并发症、填充百分比以及6个月和12个月时的愈合质量。患者平均年龄为20.5岁（范围4.7 - 75.1岁）。最常见的病变类型是单纯骨囊肿（12/28），最常见的部位是胫骨（7/28）和肱骨（7/28）。术后无病理性骨折发生。有2例（7.1%）出现伤口浆液性渗漏。平均腔隙体积为20.1 cm（范围2.7 - 101.4 cm）。在6个月和12个月时，分别有75%和77.8%的腔隙显示完全骨愈合。在12个月时，填充量>90%的腔隙中有81%显示完全骨愈合，而填充量<90%的腔隙中仅有19%显示完全骨愈合。填充牛骨移植材料在良性骨肿瘤或假肿瘤刮除术后并发症较少且愈合良好。大多数病例在12个月时实现完全愈合。填充百分比更高的腔隙X线完全融合率更高。
