Sobczak-Kupiec Agnieszka, Kudłacik-Kramarczyk Sonia, Drabczyk Anna, Cylka Karolina, Tyliszczak Bozena
Department of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31-864 Krakow, Poland.
Institute of Inorganic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31-155 Krakow, Poland.
Materials (Basel). 2023 Mar 20;16(6):2468. doi: 10.3390/ma16062468.
Tamoxifen is a well-known active substance with anticancer activity. Currently, many investigations are performed on the development of carriers that provide its effective delivery. Particular attention is directed toward the formation of cyclodextrin-drug complexes to provide prolonged drug delivery. According to our knowledge, carriers in the form of polyvinylpyrrolidone (PVP)/gelatin-based hydrogels incorporated with β-cyclodextrin-tamoxifen complexes and additionally modified with nanogold have not been presented in the literature. In this work, two series of these materials have been synthesized-with tamoxifen and with its complex with β-cyclodextrin. The process of obtaining drug carrier systems consisted of several stages. Firstly, the nanogold suspension was obtained. Next, the hydrogels were prepared via photopolymerization. The size, dispersity and optical properties of nanogold as well as the swelling properties of hydrogels, their behavior in simulated physiological liquids and the impact of these liquids on their chemical structure were verified. The release profiles of tamoxifen from composites were also determined. The developed materials showed swelling capacity, stability in tested environments that did not affect their structure, and the ability to release drugs, while the release process was much more effective in acidic conditions than in alkaline ones. This is a benefit considering their use for anticancer drug delivery, due to the fact that near cancer cells, there is an acidic environment. In the case of the composites containing the drug-β-cyclodextrin complex, a prolonged release process was achieved compared to the drug release from materials with unbound tamoxifen. In terms of the properties and the composition, the developed materials show a great application potential as drug carriers, in particular as carriers of anticancer drugs such as tamoxifen.
他莫昔芬是一种具有抗癌活性的知名活性物质。目前，针对能实现其有效递送的载体开展了许多研究。特别关注的是形成环糊精 - 药物复合物以实现药物的长效递送。据我们所知，文献中尚未提及以聚维酮（PVP）/明胶基水凝胶形式存在、结合了β - 环糊精 - 他莫昔芬复合物并额外用纳米金修饰的载体。在这项工作中，已经合成了两个系列的这些材料——含他莫昔芬的材料和含其与β - 环糊精复合物的材料。获得药物载体系统的过程包括几个阶段。首先，制备纳米金悬浮液。接下来，通过光聚合制备水凝胶。对纳米金的尺寸、分散性和光学性质以及水凝胶的溶胀性质、它们在模拟生理液体中的行为以及这些液体对其化学结构的影响进行了验证。还测定了他莫昔芬从复合材料中的释放曲线。所开发的材料表现出溶胀能力、在不影响其结构的测试环境中的稳定性以及释放药物的能力，同时释放过程在酸性条件下比在碱性条件下更有效。考虑到它们用于抗癌药物递送，这是一个优点，因为在癌细胞附近存在酸性环境。对于含有药物 - β - 环糊精复合物的复合材料，与从含有未结合他莫昔芬的材料中释放药物相比，实现了延长的释放过程。就性质和组成而言，所开发的材料作为药物载体，特别是作为他莫昔芬等抗癌药物的载体，具有很大的应用潜力。
