Loup R, Favre L, Vallotton M B
Clin Sci (Lond). 1986 Apr;70(4):371-7. doi: 10.1042/cs0700371.
To examine the response of renal prostaglandins (PG) to systemic and renal vasoconstriction noradrenaline (NA), arginine vasopressin (AVP) and angiotensin II (ANG II) were each infused into eight healthy female subjects for 3 h on different days. Urinary excretion of PGE2, PGF2 alpha and 6-keto-PGF1 alpha was determined hourly. NA and ANG II stimulated excretion of PGF2 alpha significantly, but not of PGE2 or 6-keto-PGF1 alpha. AVP stimulated renal PGF2 alpha and 6-keto-PGF1 alpha significantly, but not PGE2. A weak correlation was found between urinary PGF2 alpha and diastolic blood pressure during NA and ANG II infusions, but not during AVP infusion. The release of renal PG does not appear to constitute an obligatory and concomitant response to the blood pressure rise induced by the pressor agonists. The greater response of PGF2 alpha than of PGE2 may result from a preferential direct effect on PGF2 alpha secretion or from an increased conversion of PGE2 into F2 alpha.
为研究肾前列腺素（PG）对全身和肾血管收缩的反应，分别于不同日期给8名健康女性受试者静脉输注去甲肾上腺素（NA）、精氨酸血管加压素（AVP）和血管紧张素II（ANG II）3小时。每小时测定尿中PGE2、PGF2α和6-酮-PGF1α的排泄量。NA和ANG II显著刺激PGF2α的排泄，但对PGE2或6-酮-PGF1α无刺激作用。AVP显著刺激肾PGF2α和6-酮-PGF1α的排泄，但对PGE2无刺激作用。在输注NA和ANG II期间，尿PGF2α与舒张压之间存在弱相关性，但在输注AVP期间无此相关性。肾PG的释放似乎并非对升压激动剂引起的血压升高的必然伴随反应。PGF2α比PGE2反应更强，可能是由于对PGF2α分泌有优先直接作用，或因PGE2向F2α的转化增加。
