Transcriptomic and Proteomic Analysis of Responding to Acidic pH and Hydrogen Peroxide Stress.

is the main pathogen that causes bacterial vaginosis. In the healthy vaginal microecological environment of a woman, the lactobacilli produce lactate and hydrogen peroxide to inhibit the growth of pathogens such as . The lack of lactobacilli results in a high pH and low hydrogen peroxide in the vagina which facilitate growth, leading to the imbalance of the vaginal microecology. In this study, lactate and hydrogen peroxide were added to a culture medium to simulate the co-culture of the lactobacilli and , and then the genes related to the stress response of were identified using transcriptomics and proteomics. It was indicated that, among all the upregulated genes, most of them encoded transporters associated with the efflux of harmful substances, and the majority of the downregulated genes were related to the biofilm formation and epithelial cell adhesion. This study may help find new drug targets for for the development of novel therapies for bacterial vaginosis.