School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China.
Molecules. 2023 Mar 13;28(6):2617. doi: 10.3390/molecules28062617.
A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive control. Notably, compound displayed the broadest and most effective activity among the tested cyclotryptamine alkaloid derivatives and might be a novel potential leading compound for further development as an antifungal agent.
总共从 2-(1H-吲哚-3-基)乙腈制备了 39 种新型色胺生物碱衍生物。对所制备的化合物进行了对六种植物病原菌真菌的活性评价。生物测定结果表明，大多数化合物表现出比阳性对照物更高的体外抗真菌活性。值得注意的是，化合物 在所测试的色胺生物碱衍生物中显示出最广泛和最有效的活性，可能是进一步开发为抗真菌剂的新型潜在先导化合物。
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