Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.
Molecules. 2023 Mar 17;28(6):2737. doi: 10.3390/molecules28062737.
A heterocycle is an important structural scaffold of many organic compounds found in pharmaceuticals, materials, agrochemicals, and biological processes. Azacycles are one of the most common motifs of a heterocycle and have a variety of applications, including in pharmaceuticals. Therefore, azacycles have received significant attention from scientists and a variety of methods of synthesizing azacycles have been developed because their efficient synthesis plays a vital role in the production of many useful compounds. In this review, we summarize recent approaches to preparing azacycles via different methods as well as describe plausible reaction mechanisms.
杂环是许多药物、材料、农用化学品和生物过程中有机化合物的重要结构骨架。氮杂环是杂环中最常见的结构之一,具有多种应用,包括在药物中。因此,氮杂环受到了科学家的广泛关注,并且已经开发出了多种合成氮杂环的方法,因为其高效合成在许多有用化合物的生产中起着至关重要的作用。在这篇综述中,我们总结了通过不同方法制备氮杂环的最新方法,并描述了可能的反应机制。