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最近在合成氮杂环的路线方面的进展。

Recent Advances in Synthetic Routes to Azacycles.

机构信息

Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Republic of Korea.

Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea.

出版信息

Molecules. 2023 Mar 17;28(6):2737. doi: 10.3390/molecules28062737.

Abstract

A heterocycle is an important structural scaffold of many organic compounds found in pharmaceuticals, materials, agrochemicals, and biological processes. Azacycles are one of the most common motifs of a heterocycle and have a variety of applications, including in pharmaceuticals. Therefore, azacycles have received significant attention from scientists and a variety of methods of synthesizing azacycles have been developed because their efficient synthesis plays a vital role in the production of many useful compounds. In this review, we summarize recent approaches to preparing azacycles via different methods as well as describe plausible reaction mechanisms.

摘要

杂环是许多药物、材料、农用化学品和生物过程中有机化合物的重要结构骨架。氮杂环是杂环中最常见的结构之一,具有多种应用,包括在药物中。因此,氮杂环受到了科学家的广泛关注,并且已经开发出了多种合成氮杂环的方法,因为其高效合成在许多有用化合物的生产中起着至关重要的作用。在这篇综述中,我们总结了通过不同方法制备氮杂环的最新方法,并描述了可能的反应机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a820/10054516/43efc255a6e0/molecules-28-02737-g001.jpg

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