Senekowitsch Stefan, Foja Constantin, Wildgrube Toni, Schick Philipp, Rosenbaum Christoph, Krause Julius, Brokmann Friederike, Kromrey Marie-Luise, Engeli Stefan, Weitschies Werner, Grimm Michael
Department of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport (C_DAT), University of Greifswald, Felix-Hausdorff-Str. 3, 17487 Greifswald, Germany.
Department of Diagnostic Radiology and Neuroradiology, University Hospital Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany.
Pharmaceutics. 2023 Mar 22;15(3):1012. doi: 10.3390/pharmaceutics15031012.
Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from effervescent granules could promote the mixing of drugs into the chyme under postprandial conditions, resulting in a prolonged drug absorption. For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover study with twelve healthy volunteers, the salivary caffeine pharmacokinetics, after administration of the effervescent granules with still water and the administration of the non-effervescent granules with still and sparkling water, were investigated after intake of a standard meal. While the administration of the effervescent granules with 240 mL of still water led to a significantly prolonged gastric residence of the substance compared to the administration of the non-effervescent granules with 240 mL still water, the application of the non-effervescent granules with 240 mL sparkling water did not prolong gastric residence via mixing into caloric chyme. Overall, the mixing of caffeine into the chyme following the administration of the effervescent granules did not seem to be a motility mediated process.
据说气泡水通过释放二氧化碳来增加胃动力，从而可能影响口服药物的药代动力学。本研究的假设是，泡腾颗粒在胃内释放二氧化碳引起的胃动力增加可促进餐后药物与食糜的混合，从而延长药物吸收。为此，开发了一种泡腾颗粒剂型和一种非泡腾颗粒剂型的咖啡因作为胃排空的标志物。在一项针对12名健康志愿者的三交叉研究中，在摄入标准餐后，研究了用静水服用泡腾颗粒以及用静水和气泡水服用非泡腾颗粒后唾液中咖啡因的药代动力学。与用240毫升静水服用非泡腾颗粒相比，用240毫升静水服用泡腾颗粒导致该物质在胃内的停留时间显著延长，而用240毫升气泡水服用非泡腾颗粒并不会通过混入含热量的食糜来延长胃内停留时间。总体而言，服用泡腾颗粒后咖啡因混入食糜的过程似乎不是由动力介导的。
