Oliven A, Bassan H M
Chemotherapy. 1986;32(2):159-65. doi: 10.1159/000238408.
The effect of the antitubercular drugs rifampin and isoniazid on the function of the isolated, perfused rat liver was evaluated by monitoring the rate of bile flow and sulfobromophthalein (BSP) clearance. The effect of rifampin on bile flow was biphasic: rifampin concentration of 100 micrograms/ml increased the flow to 134% of baseline, while 1,000 micrograms/ml decreased the flow to 58% of baseline (p less than 0.01 for both). Rifampin also caused a dose-dependent inhibition of BSP removal from the perfusate and excretion in the bile. Isoniazid had no adverse effect on bile flow and BSP clearance, and the combination of isoniazid and rifampin had the same effects on the perfused liver as rifampin alone.
通过监测胆汁流量和磺溴酞钠（BSP）清除率，评估了抗结核药物利福平和异烟肼对离体灌注大鼠肝脏功能的影响。利福平对胆汁流量的影响呈双相性：100微克/毫升的利福平浓度可使流量增加至基线的134%，而1000微克/毫升则使流量降低至基线的58%（两者p均小于0.01）。利福平还导致对灌注液中BSP清除和胆汁排泄的剂量依赖性抑制。异烟肼对胆汁流量和BSP清除率无不良影响，异烟肼和利福平联合使用对灌注肝脏的影响与单独使用利福平相同。
