Rada Cara C, Yuki Kanako, Ding Jie, Kuo Calvin J
Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California 94305, USA.
Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California 94305, USA
Cold Spring Harb Perspect Med. 2023 Mar 27;13(12). doi: 10.1101/cshperspect.a041191.
The neurovascular unit is a dynamic microenvironment with tightly controlled signaling and transport coordinated by the blood-brain barrier (BBB). A properly functioning BBB allows sufficient movement of ions and macromolecules to meet the high metabolic demand of the central nervous system (CNS), while protecting the brain from pathogenic and noxious insults. This review describes the main cell types comprising the BBB and unique molecular signatures of these cells. Additionally, major signaling pathways for BBB development and maintenance are highlighted. Finally, we describe the pathophysiology of BBB diseases, their relationship to barrier dysfunction, and identify avenues for therapeutic intervention.
神经血管单元是一个动态的微环境，具有由血脑屏障（BBB）协调的严格控制的信号传导和运输。正常运作的血脑屏障允许离子和大分子充分移动，以满足中枢神经系统（CNS）的高代谢需求，同时保护大脑免受病原体和有害刺激。本综述描述了构成血脑屏障的主要细胞类型以及这些细胞独特的分子特征。此外，还强调了血脑屏障发育和维持的主要信号通路。最后，我们描述了血脑屏障疾病的病理生理学、它们与屏障功能障碍的关系，并确定了治疗干预的途径。
