School of Physical Education (Main Campus), Zhengzhou University, Zhengzhou, Henan, China.
School of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Int J Environ Health Res. 2024 Feb;34(2):1053-1063. doi: 10.1080/09603123.2023.2196396. Epub 2023 Mar 29.
Retinol-binding protein 4 (RBP4) was controversially associated with type 2 diabetes mellitus (T2DM). This meta-analysis aimed at evaluating the association between RBP4 level and T2DM risk. MEDLINE and EMBASE were searched to identify relevant studies up to 3 December 2022. Random effects model was used to pool multivariate-adjusted odds ratios () and 95% confidence intervals (). Publication bias was estimated by Funnel plot and Egger's test, it was considered to be significant when < 0.05. Eight studies including 8087 participants were finally included. Compared to those with the lowest level, subjects with the highest level of RBP4 have a higher risk of T2DM ( = 1.47, 95% : 1.16-1.78, < 0.001, = 86.9%). No publication bias among the included studies was found ( = 0.94, = 0.377). This meta-analysis indicated that high RBP4 level was associated with increasing risk of T2DM.
视黄醇结合蛋白 4（RBP4）与 2 型糖尿病（T2DM）有争议地相关。本荟萃分析旨在评估 RBP4 水平与 T2DM 风险之间的关联。检索 MEDLINE 和 EMBASE，以确定截至 2022 年 12 月 3 日的相关研究。使用随机效应模型汇总多变量调整后的优势比（OR）和 95%置信区间（CI）。通过漏斗图和 Egger 检验估计发表偏倚，当 < 0.05 时认为存在显著发表偏倚。最终纳入了 8 项研究，共 8087 名参与者。与 RBP4 水平最低的受试者相比，RBP4 水平最高的受试者患 T2DM 的风险更高（OR=1.47，95%CI：1.16-1.78， < 0.001， = 86.9%）。纳入研究中未发现发表偏倚（ = 0.94， = 0.377）。这项荟萃分析表明，高水平的 RBP4 与 T2DM 风险的增加有关。
