评估国际细胞学协会横滨系统在越南肿瘤中心报告乳腺细针穿刺细胞学的准确性。

Assessing the accuracy of the International Academy of Cytology Yokohama System for reporting breast fine needle aspiration biopsy cytology at a Vietnamese oncology centre.

机构信息

Department of Pathology, Hanoi Medical University, Hanoi, Vietnam.

Department of Pathology, Hospital 199, Da Nang, Vietnam.

出版信息

Cytopathology. 2023 Jul;34(4):325-333. doi: 10.1111/cyt.13231. Epub 2023 Mar 29.

DOI:10.1111/cyt.13231

PMID:36988122

Abstract

BACKGROUND

Fine needle aspiration biopsy (FNAB), accompanied by classification systems for cytology, can offer a cheap and convenient option for the diagnosis of breast cancer in women with suspicious breast lumps. In this study, we aimed to assess the accuracy of the International Academy of Cytology (IAC) Yokohama system in a Vietnamese oncology centre.

METHODS

A retrospective cross-sectional study was conducted from November 2021 to April 2022 at Vietnam National Cancer Hospital. We included patients with full hospital records regarding breast lesions for which FNAB was indicated. A total of 803 patients' FNAB specimens were assessed according to the IAC Yokohama system. The basic characteristics were summarised using the appropriate summary measurements. The risk of malignancy (ROM) was calculated for each classification category.

RESULTS

The median age was 42.7 years (range: 14-85). The mean size of the lesions was 17.9 mm (range: 4-123 mm). We had 215 histopathological reports. The most common benign and malignant diagnoses were fibroadenoma and invasive carcinoma, respectively. The ROM for categories II, III, IV, and V was calculated as 3.4%, 37.5%, 95%, and 99.2% respectively. The sensitivity, specificity, positive predictive value, and negative predictive value were 96.4%, 97.2%, 98.5%, and 93.2%, respectively.

CONCLUSION

The IAC Yokohama system offers a good option with which to predict underlying breast pathology using a simple and cheap procedure. However, pathologists require continuous training to ensure accurate interpretation of the slides.

摘要

背景

细针抽吸活检（FNAB）结合细胞学分类系统，为有可疑乳腺肿块的女性提供了一种廉价、便捷的乳腺癌诊断选择。本研究旨在评估国际细胞学学会（IAC）横滨系统在越南肿瘤中心的准确性。

方法

2021 年 11 月至 2022 年 4 月，在越南国家癌症医院进行了一项回顾性横断面研究。我们纳入了有完整的乳腺病变住院记录且FNAB 检查指征的患者。根据 IAC 横滨系统评估了 803 例患者的 FNAB 标本。使用适当的汇总测量方法总结基本特征。计算每个分类类别的恶性风险（ROM）。

结果

中位年龄为 42.7 岁（范围：14-85 岁）。病变的平均大小为 17.9 毫米（范围：4-123 毫米）。我们有 215 份组织病理学报告。最常见的良性和恶性诊断分别为纤维腺瘤和浸润性癌。类别 II、III、IV 和 V 的 ROM 分别计算为 3.4%、37.5%、95%和 99.2%。灵敏度、特异性、阳性预测值和阴性预测值分别为 96.4%、97.2%、98.5%和 93.2%。