皮肤肉芽肿性病变谱：砂拉越一所三级保健中心的 5 年经验。

Spectrum of cutaneous granulomatous lesions: A 5-year experience in a tertiary care centre in Sarawak.

机构信息

Sarawak General Hospital, Dermatology Department, Kuching, Sarawak, Malaysia.

出版信息

Med J Malaysia. 2023 Mar;78(2):184-189.

Abstract

INTRODUCTION

Granulomatous skin lesions can have various histopathological features leading to diagnostic confusion. The study aimed to determine the frequency and pattern of different granulomatous skin lesions.

MATERIALS AND METHODS

This was a 5-year retrospective study done between April 2017 and March 2022 at Dermatology Department, Sarawak General Hospital. Subjects with a clinicopathological diagnosis of granulomatous diseases were included in the analysis.

RESULTS

A total of 1718 skin biopsies were done during the study periods, with 49 (2.8%) confirmed granulomatous skin lesions. Most patients were aged 40-60 with a male predominance of 51%. Most of the skin biopsy samples were taken from the upper limb (36%). In this study, epitheloid granuloma was the commonest subtype (21, 43%) followed by suppurative granuloma (12, 24%), tuberculoid granuloma (8, 16%) and foreign body granuloma (5, 10%). The commonest aetiology of granulomatous skin lesions in our study was infections (30, 61%) followed by foreign body inoculation (8, 16%). Fungal infection was the most common infective cause, followed by cutaneous tuberculosis.

CONCLUSION

The major cause of granulomatous dermatoses in developing countries is still infections, fungal and tuberculosis being the leading causes.

摘要

简介

皮肤肉芽肿性病变可有多种组织病理学特征，导致诊断混淆。本研究旨在确定不同肉芽肿性皮肤病变的频率和模式。

材料和方法

这是 2017 年 4 月至 2022 年 3 月在沙捞越总医院皮肤科进行的一项为期 5 年的回顾性研究。对具有肉芽肿性疾病临床病理诊断的患者进行分析。

结果

在研究期间共进行了 1718 次皮肤活检，其中 49 例（2.8%）确诊为肉芽肿性皮肤病变。大多数患者年龄在 40-60 岁之间，男性居多，占 51%。大多数皮肤活检样本取自上肢（36%）。在本研究中，上皮样肉芽肿是最常见的亚型（21 例，43%），其次是化脓性肉芽肿（12 例，24%）、结核样肉芽肿（8 例，16%）和异物肉芽肿（5 例，10%）。本研究中肉芽肿性皮肤病变的主要病因是感染（30 例，61%），其次是异物接种（8 例，16%）。真菌感染是最常见的感染原因，其次是皮肤结核。