Orthopedics Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Food and Drug Laboratory Research Center and Food and Drug Reference Control Laboratories Center, Food and Drug Administration of Iran, MOH & ME, Tehran, Iran.
Eur J Orthop Surg Traumatol. 2023 Oct;33(7):3033-3036. doi: 10.1007/s00590-023-03522-0. Epub 2023 Mar 29.
Joint infection after Anterior Cruciate Ligament (ACL) reconstruction is an uncommon infection which can affect joint movement and function. In this study, the impact of using antibiotic during graft preparation on the results of ACL reconstruction was investigated to examine the negative effects of antibiotic solution on graft and clinical symptoms after the surgery.
In this randomized clinical trial study, 80 patients were enrolled. In one group, the graft was placed in vancomycin solution (500 mg of vancomycin powder in 100 ml of normal saline) for 10-15 min during the surgery. In other group, the surgery was performed routinely and the graft was not placed in antibiotic solution. Intravenous antibiotic was given to both groups and they underwent ACL reconstruction surgery through arthroscopic transportal technique using their hamstring tendon. Symptoms and examinations of patients were evaluated for one year after the surgery.
There was no difference between two groups in terms of knee dislocation, knee lock, pain, fever, positivity of Lachman test, Anterior drawer test and pivot-shift test, knee swelling, and movement restriction in flection and extension (P > 0.05). No infection was seen in patients.
Placing grafts in vancomycin solution does not have negative effects on graft quality and results of ACL surgery.
前交叉韧带（ACL）重建后发生关节感染是一种罕见的感染，可影响关节运动和功能。本研究旨在探讨在移植物准备过程中使用抗生素对 ACL 重建结果的影响，以检查抗生素溶液对移植物的负面影响以及手术后的临床症状。
这是一项随机临床试验研究，共纳入 80 例患者。在一组中，在手术过程中，将移植物置于万古霉素溶液（100ml 生理盐水中加入 500mg 万古霉素粉末）中 10-15 分钟。在另一组中，常规进行手术，不将移植物置于抗生素溶液中。两组均给予静脉抗生素，并通过关节镜经皮技术使用其腘绳肌腱进行 ACL 重建手术。术后 1 年对患者的症状和检查进行评估。
两组患者在膝关节脱位、膝关节锁定、疼痛、发热、Lachman 试验、前抽屉试验和枢轴转移试验阳性、膝关节肿胀以及屈伸运动受限方面无差异（P>0.05）。患者均未出现感染。
将移植物置于万古霉素溶液中不会对移植物质量和 ACL 手术结果产生负面影响。
