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[胚胎表面抗原在形成肿瘤细胞增殖自身刺激中的可能作用]

[Possible role of embryonic surface antigens in forming the autostimulus of tumor cell proliferation].

作者信息

Erkhov V S, Ageenko A I

出版信息

Eksp Onkol. 1986;8(2):32-5.

PMID:3698880
Abstract

It is shown that DNA synthesis intesifies in a mixed culture of cells of the tumours of different histogenesis, induced by monkey adenovirus SA7(C8) and chemical carcinogens, with syngenic and allogenic cells of an early embryo. This intensification of the synthesis in tumour cells is due to the contact of surfaces participating in the cell response but not to the soluble factors because when the embryo cells are placed into the milliporous chamber, the described effect is inhibited.

摘要

结果表明,在由猴腺病毒SA7(C8)和化学致癌物诱导的、不同组织发生的肿瘤细胞与早期胚胎的同基因和异基因细胞的混合培养物中,DNA合成增强。肿瘤细胞中这种合成的增强是由于参与细胞反应的表面接触,而不是可溶性因子,因为当将胚胎细胞置于微孔室中时,上述效应受到抑制。

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