School of Allied Health Science and Practice, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Exp Physiol. 2023 May;108(5):672-682. doi: 10.1113/EP091065. Epub 2023 Mar 29.
Exercise-induced hypoalgesia (EIH) has been found to vary widely within individuals with chronic neck pain (NP). Research has suggested that the presence of central sensitization within a subgroup of individuals with chronic NP might be a mediating factor to explain the relationship between exercise and improvements in patient-reported outcomes. Furthermore, recent work has found that lactate might play a role in the development and maintenance of chronic pain. The immediate effect of a single bout of physical exercise on central sensitization in individuals with chronic NP and the relationship between lactate concentration, central sensitization and pain sensitivity are to be investigated. Eighty adult participants with chronic NP will be recruited for this randomized crossover trial. Outcome measures, including temporal summation, conditioned pain modulation, EIH and lactate concentration, will be assessed before and after low- and high-intensity bicycling exercise. The outcomes of this study will provide new insights into the mechanistic effect of exercise on central sensitization in individuals with chronic NP and have the potential to add important information to the current exercise prescription guidelines for individuals with chronic NP. This study has been approved by the Human Research Ethics Committee, The University of Adelaide (H-2022-082) and registered in the Australian New Zealand Clinical Trials Registry (ACTRN12622000642785p).
运动诱导的痛觉减退（EIH）在慢性颈痛（NP）患者中个体差异很大。研究表明，慢性 NP 患者亚组中存在中枢敏化可能是解释运动与患者报告结局改善之间关系的中介因素。此外，最近的研究发现，乳酸可能在慢性疼痛的发展和维持中发挥作用。本研究旨在探究单次身体运动对慢性 NP 患者中枢敏化的即时影响，以及乳酸浓度、中枢敏化和痛觉敏感性之间的关系。这项随机交叉试验将招募 80 名慢性 NP 成年参与者。在低强度和高强度自行车运动前后，将评估包括时间总和、条件性疼痛调制、EIH 和乳酸浓度在内的结局指标。这项研究的结果将为运动对慢性 NP 患者中枢敏化的机制作用提供新的见解，并有可能为慢性 NP 患者的当前运动处方指南增加重要信息。该研究已获得阿德莱德大学人类研究伦理委员会（H-2022-082）的批准，并在澳大利亚和新西兰临床试验注册中心（ACTRN12622000642785p）注册。
