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非惊厥性癫痫持续状态:复杂部分性状态的高发病率。

Nonconvulsive status epilepticus: high incidence of complex partial status.

作者信息

Tomson T, Svanborg E, Wedlund J E

出版信息

Epilepsia. 1986 May-Jun;27(3):276-85. doi: 10.1111/j.1528-1157.1986.tb03540.x.

DOI:10.1111/j.1528-1157.1986.tb03540.x
PMID:3698940
Abstract

Nonconvulsive status epilepticus may be subdivided into generalized (absence) status and complex partial status. The latter is regarded as a rarity, whereas the former constitutes the dominant part of the hitherto reported cases. We report 10 consecutive cases of adult patients with nonconvulsive status epilepticus, all documented by ictal electroencephalographic (EEG) recordings. Five had a complex partial status; the origin of the complex partial status appeared to be frontal in four of these patients. Three had recurrent complex partial seizures with incomplete recovery between seizures, and two had more continuous symptoms. One of the latter exhibited neither motor phenomena nor automatisms. The effect of diazepam or clonazepam was immediate in all 10 cases though transient in eight. A lasting control of the status was not achieved in six patients until i.v. phenytoin was added. The difficulties in the differentiation between complex partial status and absence status despite ictal EEG recordings are discussed, illustrated by a case with seizure discharges of a focal onset which rapidly generalized. The study indicates that complex partial status may be more common and the clinical expressions of absence status more variable than hitherto recognized.

摘要

非惊厥性癫痫持续状态可细分为全身性(失神性)状态和复杂部分性状态。后者被认为较为罕见,而前者构成了迄今报道病例的主要部分。我们报告了10例连续的成年非惊厥性癫痫持续状态患者,所有病例均有发作期脑电图(EEG)记录证实。其中5例为复杂部分性状态;在这些患者中的4例,复杂部分性状态的起源似乎在额叶。3例有反复发作的复杂部分性癫痫发作,发作间期恢复不完全,2例有更持续的症状。后者中的1例既无运动现象也无自动症。地西泮或氯硝西泮在所有10例中起效迅速,不过其中8例为短暂性起效。6例患者在加用静脉注射苯妥英钠后才实现对癫痫持续状态的持久控制。尽管有发作期EEG记录,但复杂部分性状态和失神性状态之间鉴别诊断的困难仍被讨论,并通过1例发作放电起始于局灶性但迅速泛化的病例加以说明。该研究表明,复杂部分性状态可能比迄今所认识到的更为常见,而失神性状态的临床表现则更为多样。

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Diagnosis and treatment of nonconvulsive status epilepticus.非惊厥性癫痫持续状态的诊断与治疗
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