Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Odisha 752050, India.
Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Odisha 752050, India.
Int Immunopharmacol. 2023 May;118:110081. doi: 10.1016/j.intimp.2023.110081. Epub 2023 Mar 28.
The complement system is one of the oldest known tightly regulated host defense systems evolved for efficiently functioning cell-based immune systems and antibodies. Essentially, the complement system acts as a pivot between the innate and adaptive arms of the immune system. The complement system collectively represents a cocktail of ∼50 cell-bound/soluble glycoproteins directly involved in controlling infection and inflammation. Activation of the complement cascade generates complement fragments like C3a, C4a, and C5a as anaphylatoxins. C5a is the most potent proinflammatory anaphylatoxin, which is involved in inflammatory signaling in a myriad of tissues. This review provides a comprehensive overview of human C5a in the context of its structure and signaling under several pathophysiological conditions, including the current and future therapeutic applications targeting C5a.
补体系统是为高效发挥细胞免疫功能和抗体作用而进化出的最古老、调控最严密的固有宿主防御系统之一。本质上，补体系统充当着免疫系统固有和适应性免疫分支之间的枢纽。补体系统是由约 50 种细胞结合/可溶性糖蛋白组成的集合，直接参与感染和炎症的控制。补体级联的激活产生补体片段，如 C3a、C4a 和 C5a 作为过敏毒素。C5a 是最强的致炎过敏毒素，参与多种组织的炎症信号转导。本综述提供了人类 C5a 的全面概述，包括其结构和在几种病理生理条件下的信号转导，以及当前和未来针对 C5a 的治疗应用。
