Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK.
Davies Veterinary Specialists, Hitchin, SG53HR, UK.
J Small Anim Pract. 2023 Sep;64(9):590-594. doi: 10.1111/jsap.13607. Epub 2023 Mar 29.
Canine transmissible venereal tumour (CTVT) is a contagious cancer spread by transfer of living cancer cells. Occasional cases are observed in the UK in dogs imported from endemic regions. Here, we report a case of imported canine transmissible venereal tumour that was transmitted to a second dog within the UK. Transmission of genital canine transmissible venereal tumour occurred despite neutered status of the second dog. The aggressive course of disease in both cases, which included metastasis, resistance to therapeutic interventions and ultimate euthanasia of both dogs, is described. The diagnosis of canine transmissible venereal tumour was made using a combination of cytology, histology, immunohistochemistry and PCR to detect the LINE-MYC rearrangement. Practitioners unfamiliar with canine transmissible venereal tumour are reminded of this disease of concern, particularly when imported dogs are placed in multi-dog households, irrespective of neuter status.
犬传染性性病肿瘤（CTVT）是一种通过活癌细胞转移传播的传染性癌症。在英国，偶尔会从疫区进口的犬中观察到偶发病例。在这里，我们报告了一例在英国发生的进口犬传染性性病肿瘤，该肿瘤传播给了第二只犬。尽管第二只犬已绝育，但仍发生了生殖器犬传染性性病肿瘤的传播。描述了两例疾病的侵袭性病程，包括转移、对治疗干预的耐药性以及最终两只犬的安乐死。犬传染性性病肿瘤的诊断采用细胞学、组织学、免疫组织化学和 PCR 检测 LINE-MYC 重排的组合方法进行。提醒不熟悉犬传染性性病肿瘤的从业者注意这种令人关注的疾病，特别是当进口犬被安置在多犬家庭中时，无论绝育状态如何。
