Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China.
Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188885. doi: 10.1016/j.bbcan.2023.188885. Epub 2023 Mar 28.
Stress granules (SGs), non-membrane subcellular organelles made up of non-translational messenger ribonucleoproteins (mRNPs), assemble in response to various environmental stimuli in cancer cells, including pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC) which has a low 5-year survival rate of 10%. The pertinent research on SGs and pancreatic cancer has not, however, been compiled. In this review, we talk about the dynamics of SGs and their positive effects on pancreatic cancer such as SGs promote PDAC viability and repress apoptosis, meanwhile emphasizing the connection between SGs in pancreatic cancer and signature mutations such KRAS, P53, and SMAD4 as well as the functions of SGs in antitumor drug resistance. This novel stress management technique may open the door to better treatment options in the future.
应激颗粒（SGs）是由非翻译信使核糖核蛋白（mRNPs）组成的非膜亚细胞细胞器，在包括胰腺癌在内的癌细胞中对各种环境刺激作出反应，特别是胰腺导管腺癌（PDAC），其 5 年生存率仅为 10%。然而，目前尚未对 SGs 和胰腺癌的相关研究进行综述。在这篇综述中，我们讨论了 SGs 的动态及其对胰腺癌的积极影响，例如 SGs 促进 PDAC 的活力并抑制细胞凋亡，同时强调了 SGs 在胰腺癌中与标志性突变如 KRAS、P53 和 SMAD4 之间的联系以及 SGs 在抗肿瘤药物耐药性中的作用。这种新型的应激管理技术可能为未来提供更好的治疗选择。
