National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Drug Discov Ther. 2023 May 15;17(2):148-150. doi: 10.5582/ddt.2022.01104. Epub 2023 Mar 30.
Tuberculosis (TB) is a major public health problem that causes millions of deaths in humans around the world, and the bacterial pathogen Mycobacterium tuberculosis (Mtb) is responsible for this disease. Evidence suggested that the inflammasome-pyroptosis pathway is crucial for preventing Mtb infection. Uncertainty exists regarding whether and how these infections can bypass this immune system by Mtb. A recent Science article by Chai et al. (doi: 10.1126/science.abq0132) revealed a novel role by a eukaryotic-like effector called PtpB during Mtb infection. The PtpB functions as a phospholipid phosphatase suppressing gasdermin D (GSDMD) dependent pyroptosis. And notably, the phospholipid phosphatase activity of PtpB is dependent on binding with mono-ubiquitin (Ub) of the host.
结核病（TB）是一个重大的公共卫生问题，在全球范围内导致数百万人死亡，而细菌病原体结核分枝杆菌（Mtb）是导致这种疾病的罪魁祸首。有证据表明，炎症小体-细胞焦亡途径对于预防 Mtb 感染至关重要。然而，目前还不清楚 Mtb 是否以及如何能够绕过这种免疫系统。最近，Chai 等人在《科学》杂志上发表的一篇文章（doi: 10.1126/science.abq0132）揭示了一种名为 PtpB 的真核样效应物在 Mtb 感染过程中的新作用。PtpB 作为一种磷脂磷酸酶，抑制依赖于 gasdermin D（GSDMD）的细胞焦亡。值得注意的是，PtpB 的磷脂磷酸酶活性依赖于与宿主单泛素（Ub）的结合。
