Pedersen S, Steffensen G
Eur J Respir Dis. 1986 Mar;68(3):207-14.
The bronchodilator response after three different modes of inhalation of 0.2 mg fenoterol from a fenoterol powder inhaler was assessed in ten asthmatic children in a double-blind, placebo-controlled, cross-over study. There was a small, but statistically significant increase in response when the children inhaled as fast as possible, compared with very slow inhalations (16-19 l/min), but a breath-holding pause of 10 s after the inhalation had no significant effect on bronchodilation. Peak inspiratory flow through the inhaler, measured in 150 normal children aged 3.5-15 years, showed that all the children studied were able to generate a sufficient inspiratory flow to benefit from treatment with this inhaler. It is concluded that children using a fenoterol powder inhaler should be taught to inhale as fast as possible. They need not hold their breath after the inhalation.
在一项双盲、安慰剂对照、交叉研究中，对10名哮喘儿童使用非诺特罗粉雾剂吸入0.2毫克非诺特罗后三种不同吸入方式的支气管扩张反应进行了评估。与非常缓慢的吸入（16 - 19升/分钟）相比，当儿童尽可能快速吸入时，反应有小幅但具有统计学意义的增加，但吸入后屏气10秒对支气管扩张无显著影响。对150名年龄在3.5至15岁的正常儿童测量通过吸入器的最大吸气流速，结果显示所有研究的儿童都能够产生足够的吸气流速以从该吸入器治疗中获益。得出的结论是，应教导使用非诺特罗粉雾剂的儿童尽可能快速吸入。吸入后无需屏气。
