未接种疫苗患者的新冠病毒病病程——来自波兰华沙国家医院的数据
The Course of COVID-19 among Unvaccinated Patients-Data from the National Hospital in Warsaw, Poland.
作者信息
Zaczyński Artur, Hampel Michał, Piątkiewicz Paweł, Nasiłowski Jacek, Butkiewicz Sławomir, Religioni Urszula, Barańska Agnieszka, Herda Jolanta, Neumann-Podczaska Agnieszka, Vaillancourt Regis, Merks Piotr
机构信息
Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw, 02-507 Warsaw, Poland.
Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Collegium Medicum Cardinal Stefan Wyszyński, 01-815 Warsaw, Poland.
出版信息
Vaccines (Basel). 2023 Mar 16;11(3):675. doi: 10.3390/vaccines11030675.
INTRODUCTION
Studies to date indicate the relatively high effectiveness of vaccinations in preventing severe COVID-19 symptoms. However, in Poland, 40% of the population remains unvaccinated.
OBJECTIVE
The objective of this study was to describe the natural history of COVID-19 in unvaccinated hospital patients in Warsaw, Poland.
MATERIAL AND METHODS
This study evaluated data from 50 adult patients from the National Hospital in Warsaw, Poland, in the period 26 November 2021 to 11 March 2022. None of these patients had been vaccinated against COVID-19.
RESULTS
Analysis showed that the average hospitalisation time for these unvaccinated COVID-19 patients was 13 days. Clinical deterioration was observed in 70% of these patients, 40% required the intensive care unit, and 34% subsequently died prior to the end of the study.
CONCLUSIONS
There was a significant deterioration and high mortality rate in the unvaccinated patients. For this reason, it seems prudent to take measures to increase the vaccination coverage level of the population against COVID-19.
引言
迄今为止的研究表明，疫苗接种在预防严重新冠症状方面具有较高的有效性。然而，在波兰，40%的人口仍未接种疫苗。
目的
本研究的目的是描述波兰华沙未接种疫苗的住院患者的新冠自然病程。
材料与方法
本研究评估了2021年11月26日至2022年3月11日期间波兰华沙国家医院50名成年患者的数据。这些患者均未接种新冠疫苗。
结果
分析显示，这些未接种疫苗的新冠患者的平均住院时间为13天。70%的患者出现临床恶化，40%需要重症监护病房，34%随后在研究结束前死亡。
结论
未接种疫苗的患者病情显著恶化且死亡率较高。因此，采取措施提高人群针对新冠的疫苗接种覆盖率似乎是审慎之举。
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