血管紧张素转换酶水平升高表明糖尿病肾病进展或伴有视网膜损害。

Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.

作者信息

Huang Kangkang, Liang Yunlai, Wang Kun, Ma Yating, Wu Jiahui, Luo Huidan, Yi Bin

机构信息

Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China.

National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Front Clin Diabetes Healthc. 2022 May 12;3:831128. doi: 10.3389/fcdhc.2022.831128. eCollection 2022.

DOI:10.3389/fcdhc.2022.831128

PMID:36992775

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10012155/

Abstract

OBJECTIVES

Renin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear.

METHODS

Forty-four type 2 diabetes mellitus (T2DM) patients, 75 DN patients, and 36 age-gender-matched healthy volunteers were recruited who attended Xiangya Hospital of Central South University in this case control study. Serum ACE levels and other indexes were tested with commercial kit.

RESULTS

ACE levels in DN were significantly higher than T2DM and controls (F = 9.66, < 0.001). Serum ACE levels significantly correlated with UmALB (r = 0.3650, < 0.001), BUN (r = 0.3102, < 0.001), HbA1c (r = 0.2046, = 0.0221), ACR (r = 0.4187, < 0.001), ALB (r = -0.1885, = 0.0192), and eGFR (r = -0.3955, P < 0.001), and we got an equation that Y = 2.839 + 0.648X + 2.001X + 0.003X - 6.637X +0.416X - 0.134X (Y: ACE; X: BUN; X: HbA1C; X: UmALB; X: gender; X: ALB; X: eGFR, R = 0.655). When DN patients were divided into advanced-stage and early-stage with or without DR, ACE levels would increase when early-stage DN develops into advanced-stage or companied with DR.

CONCLUSION

Elevated serum ACE levels may hint DN progression or retina impaired of DN patients.

摘要

目的

肾素 - 血管紧张素 - 醛固酮系统在糖尿病肾病（DN）的发生发展中起重要作用，血管紧张素转换酶（ACE）是从血管紧张素I转化为血管紧张素II过程中的关键因素，但血清ACE在DN患者中的变化及作用仍不明确。

方法

本病例对照研究招募了44例2型糖尿病（T2DM）患者、75例DN患者以及36例年龄和性别匹配的健康志愿者，他们均来自中南大学湘雅医院。采用商用试剂盒检测血清ACE水平及其他指标。

结果

DN患者的ACE水平显著高于T2DM患者和对照组（F = 9.66，P < 0.001）。血清ACE水平与尿微量白蛋白（UmALB）（r = 0.3650，P < 0.001）、血尿素氮（BUN）（r = 0.3102，P < 0.001）、糖化血红蛋白（HbA1c）（r = 0.2046，P = 0.0221）、尿白蛋白肌酐比值（ACR）（r = 0.4187，P < 0.001）、白蛋白（ALB）（r = -0.1885，P = 有关。当DN患者根据是否伴有糖尿病视网膜病变（DR）分为晚期和早期时，早期DN发展为晚期或伴有DR时，ACE水平会升高。