2型糖尿病白种人中血管紧张素转换酶（rs4340）多态性与糖尿病肾病的关系
Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus.
作者信息
Šeruga M, Makuc J, Završnik M, Cilenšek I, Ekart R, Petrovič D
机构信息
Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia.
Department of Internal Medicine, General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
出版信息
Balkan J Med Genet. 2017 Mar 4;19(2):29-34. doi: 10.1515/bjmg-2016-0033. eCollection 2016 Dec 1.
Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme () gene and DN in Caucasians with type 2 diabetes mellitus (T2DM) in 276 Slovenian patients with T2DM who had DN, and 375 patients without clinical signs of DN. Genetic analysis was performed with either standard polymerase chain reaction (PCR) (for rs4340). Results were analyzed using the χ test and multivariate logistic regression analyses. We found no association between rs4340 and DN. Cystatin C was significantly higher in the DN+ group ( <0.001) than in the DN group. Cystatin C was a better marker for the estimation of renal function than estimated glomerular filtration rate (eGFR) according to the modification diet in renal disease (MDRD) equation mL/ min. We concluded that there was no association between the rs4340 of the gene and DN in Caucasian patients who have T2DM.
糖尿病肾病（DN）是发达国家终末期肾病（ESRD）的主要病因。多种环境和遗传因素可预测DN的发生和发展。肾素-血管紧张素系统被证实参与了DN的发生。我们评估了血管紧张素转换酶（）基因的rs4340与276例患有DN的斯洛文尼亚2型糖尿病（T2DM）白种人以及375例无DN临床体征的T2DM患者中DN的关联。采用标准聚合酶链反应（PCR）（针对rs4340）进行基因分析。结果运用χ检验和多因素逻辑回归分析进行分析。我们发现rs4340与DN之间无关联。DN阳性组的胱抑素C显著高于DN阴性组（<0.001）。根据肾病饮食改良（MDRD）公式计算的估算肾小球滤过率（eGFR）mL/ min，胱抑素C是比其更好的肾功能评估指标。我们得出结论，在患有T2DM的白种人患者中，基因的rs4340与DN之间无关联。
Zotero 插件