Zhou Peng, Bu Yu-Xin, Xu Lin, Xu Xue-Wei, Shen Hong-Bin
Key Laboratory of Marine Ecosystem Dynamics, Ministry of Natural Resources and Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou, China.
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Front Microbiol. 2023 Mar 13;14:1111472. doi: 10.3389/fmicb.2023.1111472. eCollection 2023.
Halotolerant microorganisms have developed versatile mechanisms for coping with saline stress. With the increasing number of isolated halotolerant strains and their genomes being sequenced, comparative genome analysis would help understand the mechanisms of salt tolerance. Six type strains of and , two phylogenetically close genera, were isolated from diverse salty environments and showed different NaCl tolerances, from 3 to 10% (w/v). Based on the co-occurrence greater than 0.8 between halotolerance and open reading frame (ORF) among the six strains, possible explanations for halotolerance were discussed regarding osmolyte, membrane permeability, transportation, intracellular signaling, polysaccharide biosynthesis, and SOS response, which provided hypotheses for further investigations. The strategy of analyzing genome-wide co-occurrence between genetic diversity and physiological characteristics sheds light on how microorganisms adapt to the environment.
耐盐微生物已经进化出多种应对盐胁迫的机制。随着分离出的耐盐菌株数量不断增加且其基因组被测序，比较基因组分析将有助于理解耐盐机制。从不同的咸水环境中分离出了六个 和 菌株，这两个属在系统发育上相近，它们表现出不同的NaCl耐受性，范围为3%至10%（w/v）。基于这六个菌株中耐盐性与开放阅读框（ORF）之间大于0.8的共现情况，讨论了关于渗透压调节剂、膜通透性、运输、细胞内信号传导、多糖生物合成和SOS反应的耐盐性可能解释，这为进一步研究提供了假设。分析遗传多样性与生理特征之间全基因组共现的策略揭示了微生物如何适应环境。
