Das Anamika, Datta Anupam, Nath Anamika, Bhowmik Anirban
Department of General Medicine, Hapania, Agartala, Tripura, India.
Department of Assistant Professor, Forensic Medicine and Toxicology, Hapania, Agartala, Tripura, India.
J Family Med Prim Care. 2022 Nov;11(11):7072-7076. doi: 10.4103/jfmpc.jfmpc_1076_22. Epub 2022 Dec 16.
Poisoning has been one of the greatest medical emergencies from the dawn of human civilization, posing threat to mankind. Tripura being a seven sister state of Northeast India have a unique topography, diverse ethnic groups, cross-cultural food habits, agriculture, and a horticulture-based economy that draws some distinctive type of poisoning threats compared to the rest of the Indian subcontinent. The present study was carried out to find out the epidemiological factors, toxicological profiles, and clinical outcomes of patients after consumption of poison.
A cross-sectional study on 212 patients with a complaint of poisoning was conducted in a teaching hospital in Tripura, India, for 2 years, and the data were analyzed by using SPSS-15 (Statistical Package for the Social Sciences) software.
Out of 212 participants, males from lower socioeconomic status, farmers by occupation, and belonging to the age group of 21-30 years predominated other categories. Organophosphorus compounds were majorly ingested (38.7%). Suicide was the most common manner of poisoning (62.73%). The majority of the patients (75%) died during treatment, 39.15% of patients died in the initial 24 hours and 43.87% of the patients had severe life-threatening symptoms [grade 3 of poison severity score (PSS)] during the first 72 hours of hospital admission. A Spearman rho value of -0.740 and a value <0.001 were found while establishing a relationship between survival time and PSS.
Poisoning by any agents and means produces adverse effects on the human body which further influences the clinical outcome. Therefore, proper knowledge and attention regarding its clinico-toxico-epidemiological profile, accurate and timely diagnosis, and satisfactory management and prevention strategies are necessary.
自人类文明伊始，中毒就一直是最严重的医疗急症之一，对人类构成威胁。特里普拉邦是印度东北部的一个七邦之一，拥有独特的地形、多样的民族、跨文化的饮食习惯、农业以及以园艺为基础的经济，与印度次大陆其他地区相比，面临着一些独特类型的中毒威胁。本研究旨在找出中毒患者的流行病学因素、毒理学特征及临床结局。
在印度特里普拉邦的一家教学医院，对212例有中毒主诉的患者进行了为期2年的横断面研究，并使用SPSS - 15（社会科学统计软件包）软件对数据进行分析。
在212名参与者中，社会经济地位较低、职业为农民且年龄在21 - 30岁的男性占比高于其他类别。有机磷化合物是主要摄入的毒物（38.7%）。自杀是最常见的中毒方式（62.73%）。大多数患者（75%）在治疗期间死亡，39.15%的患者在最初24小时内死亡，43.87%的患者在入院后的前72小时出现严重的危及生命的症状[中毒严重程度评分（PSS）3级]。在建立生存时间与PSS之间的关系时，发现Spearman相关系数为 - 0.740，P值<0.001。
任何毒物和方式导致的中毒都会对人体产生不良影响，进而影响临床结局。因此，有必要对其临床 - 毒理学 - 流行病学特征有适当的了解和关注，进行准确及时的诊断，并采取令人满意的管理和预防策略。
