Krasavage W J
Fundam Appl Toxicol. 1986 Feb;6(2):349-55. doi: 10.1016/0272-0590(86)90250-2.
Adult male rats (Crl:COBS CD (SD)BR) were given undiluted ethylene glycol monobutyl ether (EGBE) by gavage in doses of 222, 443, or 885 mg/kg/day, 5 days/week over a 6-week period. A dose-dependent decrease, which was statistically significant at the high dose, was seen in body weight gain. Feed consumption was also significantly reduced at the 885-mg/kg dose. The most significant toxic effects produced by EGBE were on the red blood cells including a significant dose-dependent decrease in hemoglobin concentration, red blood cell counts, and mean corpuscular hemoglobin concentration. Mean corpuscular hemoglobin and mean corpuscular volume were increased at all dose levels. Effects secondary to the red cell effects included increased spleen weights, splenic congestion, and hemosiderin accumulation in the liver and kidneys. Relative liver weights and serum alkaline phosphatase (443- and 885-mg/kg doses) and serum alanine aminotransferase (885-mg/kg dose) levels were increased. Glucose was significantly reduced in the animals given 885 mg/kg/day. EGBE had no adverse effects on the testes, bone marrow, thymus, or white blood cells.
成年雄性大鼠（Crl:COBS CD (SD)BR）通过灌胃给予未稀释的乙二醇单丁醚（EGBE），剂量分别为222、443或885毫克/千克/天，每周5天，持续6周。体重增加出现剂量依赖性下降，高剂量组具有统计学显著性。885毫克/千克剂量组的饲料消耗量也显著降低。EGBE产生的最显著毒性作用是对红细胞的影响，包括血红蛋白浓度、红细胞计数和平均红细胞血红蛋白浓度出现显著的剂量依赖性下降。所有剂量水平下平均红细胞血红蛋白和平均红细胞体积均增加。红细胞效应的继发影响包括脾脏重量增加、脾充血以及肝脏和肾脏中铁蛋白沉积。相对肝脏重量以及血清碱性磷酸酶（443和885毫克/千克剂量组）和血清丙氨酸氨基转移酶（885毫克/千克剂量组）水平升高。给予885毫克/千克/天的动物血糖显著降低。EGBE对睾丸、骨髓、胸腺或白细胞没有不良影响。
