O'Donoghue J L
Fundam Appl Toxicol. 1986 Apr;6(3):551-8.
4-Chloro-3-nitroaniline was given to groups of 20 male and 20 female rats by gavage at doses of 3.6, 18, or 90 mg/kg in a 10% corn oil suspension. Doses were administered 5 days per week for 90 days. The high dose resulted in reduced body weight gain in males, reduced feed consumption and fluctuating feed consumption in both sexes, slight hemolytic anemia with Heinz bodies in both sexes, enlargement of the spleen due to congestion, hemosiderosis, and increased extramedullary hematopoiesis in both sexes, inflammatory changes in the splenic capsules of two females, hemosiderin pigmentation of the liver in both sexes, bone marrow hyperplasia in both sexes, increased liver weight in females, and testicular atrophy. The middle dose produced a fluctuating feed consumption pattern in males, Heinz bodies in both sexes, very slight anemia in females, splenic hemosiderosis in males, slightly increased splenic extramedullary hematopoiesis in females, hemosiderin pigmentation of the liver in males, and possibly increased liver weight in females, and inflammatory changes in the splenic capsule of one male. The low dose produced Heinz bodies in males and possibly females although the Heinz body counts of females were not statistically significant. The primary toxicologic damage produced by 4-chloro-3-nitroaniline is hemolytic or Heinz body anemia and testicular atrophy. Thus the toxicity of 4-chloro-3-nitroaniline is similar to that of other aromatic nitro and amino chemicals.
将20只雄性和20只雌性大鼠分为几组，通过灌胃给予其10%玉米油混悬液形式的4-氯-3-硝基苯胺，剂量分别为3.6、18或90mg/kg。每周给药5天，持续90天。高剂量导致雄性大鼠体重增加减少，两性的采食量均减少且采食量波动，两性均出现轻度溶血性贫血并伴有海因茨小体，两性脾脏因充血、含铁血黄素沉着和髓外造血增加而肿大，两只雌性大鼠脾包膜出现炎症变化，两性肝脏均有含铁血黄素沉着，两性骨髓增生，雌性大鼠肝脏重量增加以及睾丸萎缩。中剂量使雄性大鼠采食量出现波动模式，两性均出现海因茨小体，雌性大鼠出现非常轻微的贫血，雄性大鼠脾脏有含铁血黄素沉着，雌性大鼠脾脏髓外造血略有增加，雄性大鼠肝脏有含铁血黄素沉着，雌性大鼠肝脏重量可能增加，以及一只雄性大鼠脾包膜出现炎症变化。低剂量使雄性大鼠出现海因茨小体，雌性大鼠可能也出现海因茨小体，不过雌性大鼠的海因茨小体计数无统计学意义。4-氯-3-硝基苯胺产生的主要毒理学损害是溶血性或海因茨小体贫血以及睾丸萎缩。因此，4-氯-3-硝基苯胺的毒性与其他芳香族硝基和氨基化学品的毒性相似。
