Karamooz Elham, Brixey Anupama G, Rydzak Chara E, Primack Steven L, Markwardt Sheila, Barker Alan F
Oregon Health & Science University Pulmonary & Critical Care.
Cardiothoracic Imaging Section, Department of Diagnostic Radiology, Oregon Health & Science University.
Res Sq. 2023 Mar 22:rs.3.rs-2711488. doi: 10.21203/rs.3.rs-2711488/v1.
Although pulmonary artery (PA) dilation is independently associated with significant morbidity and mortality in patients with pulmonary diseases irrespective of diagnosed pulmonary hypertension, its relationship to nontuberculous mycobacteria (NTM) is unknown. To determine the prevalence of PA dilation in patients with NTM-predominant non-CF bronchiectasis, we evaluated the chest computed tomography (CT) scans from 321 patient in the United States based Bronchiectasis and NTM Research Registry. The majority of our cohort had NTM infection. We measured the severity of bronchiectasis using modified Reiff criteria and measured the diameters of the PA and aorta (Ao), with PA dilation defined as a PA:Ao ratio > 0.9. Forty-two patients (13%) were found to have PA dilation. PA dilation was positively associated with the use of supplemental oxygen ( < 0.001), but there was no association between PA dilation and NTM infection.
尽管肺动脉（PA）扩张与肺部疾病患者的显著发病率和死亡率独立相关，无论是否诊断为肺动脉高压，但其与非结核分枝杆菌（NTM）的关系尚不清楚。为了确定以NTM为主的非囊性纤维化支气管扩张患者中PA扩张的患病率，我们评估了美国支气管扩张和NTM研究登记处321例患者的胸部计算机断层扫描（CT）。我们队列中的大多数患者患有NTM感染。我们使用改良的Reiff标准测量支气管扩张的严重程度，并测量PA和主动脉（Ao）的直径，PA扩张定义为PA:Ao比值>0.9。42例患者（13%）被发现有PA扩张。PA扩张与补充氧气的使用呈正相关（<0.001），但PA扩张与NTM感染之间没有关联。
