维拉帕米和硝苯地平对豚鼠离体肺实质条作用的药理学特性
Pharmacological characterization of the effects of verapamil and nifedipine on isolated guinea-pig lung parenchymal strip.
作者信息
Cortijo J, Perpiñá M, Esplugues J, Morcillo E J
出版信息
Gen Pharmacol. 1986;17(2):211-7. doi: 10.1016/0306-3623(86)90141-2.
PMID:3699447
Abstract
Verapamil and nifedipine elicited dose-related relaxations and produced a right downward shift of the concentration-response curves to CaCl2, KCl, acetylcholine and histamine in the isolated guinea-pig lung parenchymal strip. These Ca-entry blockers had greater inhibitory effects on contractions evoked by CaCl2 and KCl than against those elicited by acetylcholine and histamine.
摘要
维拉帕米和硝苯地平引起剂量相关的舒张反应，并使离体豚鼠肺实质条对氯化钙、氯化钾、乙酰胆碱和组胺的浓度-反应曲线向右下方移位。这些钙通道阻滞剂对氯化钙和氯化钾诱发的收缩的抑制作用比对乙酰胆碱和组胺诱发的收缩的抑制作用更强。
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