Department of Radiology, Çukurova University Faculty of Medicine, Balçalı Hospital Health Application and Research Center, Adana, Turkey.
Department of Nuclear Medicine, Çukurova University Faculty of Medicine, Balçalı Hospital Health Application and Research Center, Adana, Turkey.
Diagn Interv Radiol. 2023 Sep 5;29(5):704-709. doi: 10.4274/dir.2021.211255. Epub 2022 Dec 28.
To analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttrium- 90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.
Interleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 patients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.
In the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treatment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 ( = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders ( = 0.036).
Short-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recognition of non-responders.
分析经钇-90 载药树脂微球肝动脉栓塞化疗（TARE）治疗肝细胞癌（HCC）患者后血管生成因子的变化。
检测 26 例 HCC 患者 TARE 前及 TARE 后第 1、7、14、30 天的白细胞介素-6、白细胞介素-8、肝细胞生长因子、血小板衍生生长因子、成纤维细胞生长因子、血管内皮生长因子-A（VEGF-A）和血管生成素-2 水平，并评估其与影像学反应的关系。
在 6 个月的随访中，11 例（42.30%）患者对治疗有完全或部分反应，而 15 例（57.69%）患者发现疾病进展。TARE 后 30 天无反应者 VEGF-A 的百分比变化（ = 0.034）明显更明显。无反应者的 VEGF-A 峰值形成率更高（ = 0.036）。
经钇-90 载药树脂微球 TARE 治疗后 HCC 患者的血管生成因子在短期内会随时间的不同而呈不同幅度的波动。生长因子的上调具有预后能力。TARE 后 VEGF-A 的变化可能有助于早期识别无反应者。
