Department of Internal Medicine and Clinical Pharmacology, School of Medicine, Medical University of Silesia, Katowice, Poland.
Department of Radiodiagnostics, Invasive Radiology and Nuclear Medicine, Department of Radiology and Nuclear Medicine, School of Medicine, Medical University of Silesia, Katowice, Poland.
Adv Clin Exp Med. 2023 Oct;32(10):1125-1132. doi: 10.17219/acem/161158.
On March 11, 2020, coronavirus disease (COVID-19) was declared a global threat by the World Health Organization (WHO). It quickly became apparent that reducing inpatient mortality rates and early phase prediction of possible deterioration or severe disease course relied on finding more specific biomarkers.
This retrospective study assessed initial clinical, laboratory and radiological features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients and explored their impact on mortality and the course of the disease. Such efforts aimed to facilitate the identification of high-risk patients and to improve the formulation of treatment plans for these individuals.
The cohort comprised 111 consecutive adult inpatients diagnosed with COVID-19 and hospitalized in the Internal Medicine Ward of the University Clinical Center of prof. K. Gibiński of the Medical University of Silesia in Katowice, Poland, a COVID-19 Treatment Unit, between November 16, 2020 and February 15, 2021. All available clinical, laboratory and radiological findings were extracted from electronic records and assessed as possible risk factors for poor prognosis.
Clinicasl and radiological features with higher frequency in COVID-19 non-survivors included older age, history of smoking, concomitant cardiovascular diseases, low oxygen saturation (SpO2), and high infection risk assessed on admission as well as high opacity score, percentage of opacity and percentage of high opacity in computed tomography. Non-survivors had decreased serum lymphocytes, monocytes, calcium, magnesium, and hemoglobin oxygen saturation. They also had increased red cell distribution width (RDW), C-reactive protein (CRP), procalcitonin, alkaline phosphatase (ALP), creatinine, blood urea nitrogen (BUN), D-dimer, troponin, and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels, as well as a base deficit.
This retrospective study identified several markers associated with a fatal course of COVID-19. The early assessment of SARS-CoV-2-infected inpatients should consider these markers.
2020 年 3 月 11 日，世界卫生组织（WHO）宣布冠状病毒病（COVID-19）为全球威胁。很快就明显看出，降低住院死亡率和早期预测可能恶化或严重疾病过程依赖于寻找更具体的生物标志物。
本回顾性研究评估了严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染患者的初始临床、实验室和影像学特征，并探讨了它们对死亡率和疾病过程的影响。这些努力旨在帮助识别高危患者，并为这些患者制定更好的治疗计划。
该队列包括 2020 年 11 月 16 日至 2021 年 2 月 15 日期间在波兰西里西亚医科大学卡托维兹大学临床中心（COVID-19 治疗单位）住院的 111 例连续成年 COVID-19 住院患者。从电子病历中提取所有可用的临床、实验室和影像学发现，并评估为不良预后的可能危险因素。
COVID-19 非幸存者中更常见的临床和影像学特征包括年龄较大、吸烟史、并存心血管疾病、低血氧饱和度（SpO2）以及入院时评估的高感染风险，以及高混浊评分、混浊百分比和计算机断层扫描中的高混浊百分比。非幸存者的血清淋巴细胞、单核细胞、钙、镁和血红蛋白氧饱和度降低。他们还具有更高的红细胞分布宽度（RDW）、C 反应蛋白（CRP）、降钙素、碱性磷酸酶（ALP）、肌酐、血尿素氮（BUN）、D-二聚体、肌钙蛋白和脑钠肽前体（NT-proBNP）水平，以及碱剩余。
本回顾性研究确定了与 COVID-19 致命病程相关的几个标志物。应考虑这些标志物对 SARS-CoV-2 感染住院患者的早期评估。
