Institute of Biomedical Research in Malaga (IBIMA), 29010 Malaga, Spain.
Department of Anaesthesiology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain.
Curr Gene Ther. 2023;23(4):261-275. doi: 10.2174/1566523223666230328165109.
Currently, an increasing prevalence has been reported in incidences of tumor pathologies. The influence of anesthetics drugs has been the subject of numerous studies. It has been reported that the use of certain drugs may have an impact on prognosis and survival. By investigating the action of these drugs on different metabolic pathways and their mechanisms of action, we can better understand how they influence various hallmarks of carcinogenesis and determine their potential impact on cancer progression. Some of the action pathways are widely known within oncology, being targets of specific treatments, such as PI3k/AKT/mTOR, EGFR, and Wnt/ β-catenin. This review performs a thorough dissection of the interaction between anesthetic drugs and oncological cell lines through cell signaling pathways and genetic, immune, and transcriptomic pathways. Through these underlying mechanisms, it aims to clarify the effect of the choice of anesthetic drug and its potential influence on the prognosis of oncological surgery.
目前，肿瘤病理学发病率的上升趋势越来越明显。麻醉药物的影响一直是许多研究的主题。有报道称，某些药物的使用可能会对预后和生存产生影响。通过研究这些药物对不同代谢途径的作用及其作用机制，我们可以更好地了解它们如何影响致癌过程的不同特征，并确定它们对癌症进展的潜在影响。其中一些作用途径在肿瘤学中广为人知，是特定治疗方法的靶点，如 PI3k/AKT/mTOR、EGFR 和 Wnt/β-catenin。本综述通过细胞信号通路以及遗传、免疫和转录组学通路，对麻醉药物与肿瘤细胞系之间的相互作用进行了深入剖析。通过这些潜在的机制，旨在阐明麻醉药物选择的效果及其对肿瘤手术预后的潜在影响。
