From the Mallinckrodt Institute of Radiology (A.S.P., F.D., R.L.W.) and Siteman Cancer Center (F.D., R.L.W.), Washington University School of Medicine, 4525 Scott Ave, East Building, #3433, St Louis, MO 63110.
Radiographics. 2023 Apr;43(4):e220122. doi: 10.1148/rg.220122.
Response is the logical outcome measure of a treatment in a clinical or research setting. Objective response assessment involves the use of a test to segregate patients who are likely to experience improved survival from those who are not. Early and accurate response assessment is critical for determining therapy effectiveness in clinical settings, for effective trial designs comparing two or more therapies, and for modulating treatment on the basis of response (ie, response-adapted therapy). 2-[fluorine 18]fluoro-2-deoxy-d-glucose (FDG) PET/CT can provide both functional and structural information about a disease process. It has been used at several stages of patient management, including imaging-based tumor response assessment, for various malignancies. FDG PET/CT can be used to differentiate patients with lymphoma who have a residual mass but no residual disease after treatment (ie, complete responders) from those who have a residual mass and residual disease after treatment. Similarly, in solid malignancies, the functional changes in glucose uptake and metabolism precede the structural changes (commonly seen as tumor shrinkage) and necrosis. Response assessment criteria have been developed on the basis of findings on FDG PET/CT images and are continuously being revised to ensure standardization and improve their predictive performance. Published under a CC BY 4.0 license. Quiz questions for this article are available through the Online Learning Center.
反应是临床或研究环境中治疗的逻辑结果衡量标准。客观反应评估涉及使用测试将可能经历生存改善的患者与未经历生存改善的患者区分开来。早期和准确的反应评估对于确定临床环境中的治疗效果、比较两种或多种治疗方法的有效试验设计以及基于反应来调整治疗（即反应适应性治疗）至关重要。2-[氟-18]氟-2-脱氧-d-葡萄糖（FDG）PET/CT 可提供关于疾病过程的功能和结构信息。它已在患者管理的几个阶段使用，包括基于成像的肿瘤反应评估，用于各种恶性肿瘤。FDG PET/CT 可用于区分治疗后仍有残留肿块但无残留疾病的淋巴瘤患者（即完全缓解者）和治疗后仍有残留肿块和残留疾病的患者。同样，在实体恶性肿瘤中，葡萄糖摄取和代谢的功能变化先于结构变化（通常表现为肿瘤缩小）和坏死。反应评估标准是基于 FDG PET/CT 图像的发现制定的，并在不断修订，以确保标准化并提高其预测性能。根据知识共享署名 4.0 国际许可协议发布。本文的测验问题可通过在线学习中心获得。
