School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab 147301, India.
Fitoterapia. 2023 Jun;167:105492. doi: 10.1016/j.fitote.2023.105492. Epub 2023 Mar 28.
Genus Leucas (family Lamiaceae) has been used as the traditional medicine for the treatment of a variety of disorders like skin diseases, diabetes, rheumatic pain, wounds, snake bites, etc. Several species of genus Leucas have been explored for their pharmacological activities and found to possess diverse properties like antimicrobial, antioxidant, anti-inflammatory, cytotoxic and anticancer, antinociceptive, antidiabetic, antitussive, wound healing, phytotoxic, etc. Phytochemical investigations of the different plant parts of Genus Leucas have revealed the presence of phytochemicals including terpenoids, flavonoids, lignans, phenolic glycosides, sterols, and essential oils. Terpenoids have been obtained as the major components of the isolated compounds and could be used as the marker compounds for the genus Leucas. The traditional uses of Leucas spp. have been established scientifically and were shown due to the presence of different phytochemicals. Although the pharmacological activities of Leucas plants have been well-documented, further studies are needed to fully understand their mechanisms of action and clinical applications. In conclusion, the phytochemistry and pharmacological activity of genus Leucas make it a promising source of natural products for drug discovery and development. The present review aims to provide a comprehensive note on the phytochemistry and pharmacological properties of the genus Leucas.
唇形科野芝麻属（Leucas）植物作为传统药物，已被广泛用于治疗多种疾病，如皮肤病、糖尿病、风湿痛、创伤、蛇咬伤等。研究发现，该属的多个种具有多种药理学活性，包括抗菌、抗氧化、抗炎、细胞毒性和抗癌、镇痛、抗糖尿病、镇咳、愈伤、植物毒性等。对野芝麻属不同植物部位的植物化学研究表明，存在包括萜类、类黄酮、木脂素、酚糖苷、甾醇和精油在内的多种植物化学物质。萜类化合物已被分离为主要成分，可作为野芝麻属的标记化合物。野芝麻属植物的传统用途已得到科学证实，这归因于其含有多种不同的植物化学物质。尽管野芝麻属植物的药理学活性已有充分的文献记载，但仍需要进一步研究以充分了解其作用机制和临床应用。总之，野芝麻属植物的植物化学和药理学活性使其成为天然产物药物发现和开发的有前途的来源。本综述旨在全面介绍野芝麻属植物的植物化学和药理学特性。
