Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
Department of Ambulatory Medicine, The Fifth Medical Center of Chinese PLA General Hospital, Beijng, China.
Asia Pac J Clin Nutr. 2023;32(1):57-62. doi: 10.6133/apjcn.202303_32(1).0009.
To describe nutritional status and inflammation of elderly patients with chronic kidney disease and to confirm the association between a Malnutrition-Inflammation Score and physical func-tion and functional disability.
A total of 221 chronic kidney disease patients (aged ≥60 years) were included. A Malnutrition-Inflammation Score was used to assess malnutrition and inflammation. Physical function was assessed using the SF-12. Functional status was evaluated using basic activities of daily living and instrumental activities of daily living.
Thirty percent of participants had a Malnutrition-Inflammation Score ≥6, which denoted poor nutritional status. Participants with a Malnutrition-Inflammation Score ≥6 had decreased concentration of hemoglobin, albumin, prealbumin, handgrip strength and walking speed and increased concentration of inflammatory markers, including CRP, IL-6 and fibrinogen. Physical function and physical component summary were lower and basic activities of daily living dependence and instrumental activities of daily living dependence were higher among patients with higher Malnutrition-Inflammation Score than those with a lower Malnutrition-Inflammation Score. The Malnutrition-Inflammation Score was an independent risk factor for physical function and instrumental activities of daily living dependence.
The elderly chronic kidney disease patients with a high Malnutrition-Inflammation Score had a decreased physical function and an increased risk of functional instrumental activities of daily living dependence.
描述老年慢性肾脏病患者的营养状况和炎症情况，并确认营养不良-炎症评分与身体功能和功能障碍之间的关系。
共纳入 221 名年龄≥60 岁的慢性肾脏病患者。采用营养不良-炎症评分评估营养不良和炎症情况。使用 SF-12 评估身体功能。通过基本日常生活活动和工具性日常生活活动评估功能状态。
30%的参与者营养不良-炎症评分≥6，提示存在营养不良。营养不良-炎症评分≥6 的患者血红蛋白、白蛋白、前白蛋白、握力和步行速度降低，炎症标志物如 CRP、IL-6 和纤维蛋白原浓度升高。与营养不良-炎症评分较低的患者相比，评分较高的患者身体功能和生理成分综合评分较低，基本日常生活活动依赖和工具性日常生活活动依赖较高。营养不良-炎症评分是身体功能和工具性日常生活活动依赖的独立危险因素。
营养不良-炎症评分较高的老年慢性肾脏病患者身体功能下降，发生功能性工具性日常生活活动依赖的风险增加。
