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[海南省百岁老人营养状况与抑郁之间的关联]

[Association between nutritional status and depression among centenarians in Hainan Province].

作者信息

Song Y, Han K, Jia W P, Wang S S, Zhu Q, Ning C X, Liu M, Zhao Y L, He Y

机构信息

Institute of Geriatrics, the Second Medical Center & National Clinical Research Center for Geriatrics Diseases, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, Beijing 100853, China.

Central Laboratory of Hainan Hospital, Chinese PLA General Hospital, Sanya 572013, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2022 Jan 11;102(2):114-118. doi: 10.3760/cma.j.cn112137-20210520-01171.

Abstract

To explore the relationship between nutritional status and depression of centenarians in Hainan Province. A total of 1 002 elderly people in Hainan Province who were 100 years of age or older on June 1, 2014 were included in the study. The basic condition questionnaire, Mini Nutritional Assessment Short-Form (MNA-SF), Instrumental Activities of Daily Living-Lawton scale (Lawton-IADL) and Geriatric Depression Scale (GDS-15) were used to collect the subjects' demographic characteristics, disease history, nutritional status, functional status of daily activities, and depression, respectively. The restricted cubic spline fitting logistic regression model was used to analyze the relationship between the scores of MNA-SF and depression. The multivariable logistic regression model was used to analyze the relationship between nutritional status and depression in the total population and different subgroups of daily activity function. The (, ) of subjects' age was 102 (101, 104) years old, among which 82.0% (822) were women. The prevalence of malnutrition, impaired daily activities, and depression was 20.8% (208 cases), 64.7% (648 cases) and 28.5%(286 cases), respectively. Restricted cubic spline fitting logistic regression model showed a linear association between the scores of the MNA-SF and depression (=0.251). The higher the MNA-SF score was, the lower the risk of depression was in centenarians. Multivariable logistic regression model analysis showed that after adjusting for sex, education level, diabetes, hypertension, coronary heart disease, visual function, hearing function, and functional status of daily activities, malnutrition was positively associated with the development of depression in the total population and the subgroup with impaired daily activities [ (95%) was 1.50 (1.07-2.11) and 1.56 (1.09-2.24), respectively], but not in the subgroup with good daily activities [ (95%): 0.77 (0.21-2.80)]. Malnutrition is positively associated with depression, especially in the centenarians with impaired daily activities.

摘要

为探讨海南省百岁老人营养状况与抑郁之间的关系。本研究纳入了2014年6月1日时年龄在100岁及以上的1002名海南省老年人。使用基本情况问卷、微型营养评定简表(MNA-SF)、日常生活能力量表(Lawton-IADL)和老年抑郁量表(GDS-15)分别收集受试者的人口统计学特征、病史、营养状况、日常活动功能状态和抑郁情况。采用受限立方样条拟合逻辑回归模型分析MNA-SF得分与抑郁之间的关系。采用多变量逻辑回归模型分析总体人群及日常活动功能不同亚组中营养状况与抑郁之间的关系。受试者年龄的中位数(四分位数间距)为102(101,104)岁,其中82.0%(822名)为女性。营养不良、日常活动能力受损和抑郁的患病率分别为20.8%(208例)、64.7%(648例)和28.5%(286例)。受限立方样条拟合逻辑回归模型显示MNA-SF得分与抑郁之间呈线性关联(P=0.251)。百岁老人中,MNA-SF得分越高,抑郁风险越低。多变量逻辑回归模型分析显示,在调整性别、教育水平、糖尿病、高血压、冠心病、视觉功能、听觉功能和日常活动功能状态后,营养不良与总体人群及日常活动能力受损亚组中抑郁的发生呈正相关[比值比(95%置信区间)分别为1.50(1.07-2.11)和1.56(1.09-2.24)],但在日常活动能力良好亚组中无相关性[比值比(95%置信区间):0.77(0.21-2.80)]。营养不良与抑郁呈正相关,尤其是在日常活动能力受损的百岁老人中。

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