Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Department of Joint Surgery, Ganzhou People's Hospital, Ganzhou, China.
Front Endocrinol (Lausanne). 2023 Mar 14;14:1117489. doi: 10.3389/fendo.2023.1117489. eCollection 2023.
Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for treating OA. Flavonoids are a class of naturally occurring polyphenols with anti-inflammatory properties. Structurally, natural flavonoids can be divided into several sub-groups, including flavonols, flavones, flavanols/catechins, flavanones, anthocyanins, and isoflavones. Increasing evidence demonstrates that natural flavonoids exhibit protective activity against the pathological changes of OA by inhibiting the NF-κB signaling pathway. Potentially, natural flavonoids may suppress NF-κB signaling-mediated inflammatory responses, ECM degradation, and chondrocyte apoptosis. The different biological actions of natural flavonoids against the NF-κB signaling pathway in OA chondrocytes might be associated with the differentially substituted groups on the structures. In this review, the efficacy and action mechanism of natural flavonoids against the development of OA are discussed by targeting the NF-κB signaling pathway. Potentially, flavonoids could become useful inhibitors of the NF-κB signaling pathway for the therapeutic management of OA.
骨关节炎（OA）是一种与慢性炎症相关的典型关节疾病。核因子-κB（NF-κB）途径在炎症活性中起重要作用，抑制 NF-κB 介导的炎症可能是治疗 OA 的一种潜在策略。类黄酮是一类具有抗炎特性的天然多酚。从结构上看，天然类黄酮可分为几类亚组，包括黄酮醇、黄酮、黄烷醇/儿茶素、黄烷酮、花青素和异黄酮。越来越多的证据表明，天然类黄酮通过抑制 NF-κB 信号通路，表现出对 OA 病理变化的保护作用。天然类黄酮可能通过抑制 NF-κB 信号转导介导的炎症反应、细胞外基质降解和软骨细胞凋亡来抑制 NF-κB 信号通路。天然类黄酮对 OA 软骨细胞中 NF-κB 信号通路的不同生物学作用可能与结构上不同取代基有关。在本综述中，通过针对 NF-κB 信号通路讨论了天然类黄酮对 OA 发展的疗效和作用机制。类黄酮可能成为 NF-κB 信号通路的有用抑制剂，用于 OA 的治疗管理。
