Bi Chenyang, Wang Zhe, Xiao Yafei, Zhao Ying, Guo Runjiang, Xiong Luyao, Ji Zhiyu, Li Yifan, Li Quanying, Qin Changjiang
Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng, China.
Front Genet. 2023 Mar 14;14:1138137. doi: 10.3389/fgene.2023.1138137. eCollection 2023.
Human chromosome 12 contains I kappa B kinase interacting protein (IKBIP) is also commonly known as IKIP. The involvement of IKBIP in the growth of tumors has only been discussed in a small number of publications. To explore the role that IKBIP plays in the development of a wide variety of neoplasms, as well as the tumor immunological microenvironment. UALCAN, HPA, Genotype Tissue Expression, Cancer Genome Maps, and other datasets were used to analyze IKBIP expression. We thoroughly investigated the predictive importance of IKBIP in pan-cancer, clinical traits, and genetic anomalies. We studied whether there is a link between IKBIP and immune-related genes, microsatellite instability (MSI), and the incidence of tumor mutational burden (TMB). The link between immune cell infiltration and IKBIP expression was examined using data on immune cell infiltration from ImmuCellAI, TIMER2, and earlier studies. Finally, gene set enrichment analysis (GSEA) was performed to determine the signaling pathways associated with IKBIP. IKBIP is highly expressed in most cancers and is negatively associated with the prognosis of several major cancer types. Furthermore, IKBIP expression was linked to TMB in 13 cancers and MSI in seven cancers. Additionally, IKBIP is associated with numerous immunological and cancer-promoting pathways. Simultaneously, various cancer types have unique tumor-infiltrating immune cell profiles. IKBIP has the potential to act as a pan-cancer oncogene and is crucial for both carcinogenesis and cancer immunity. Elevated IKBIP expression implies an immunosuppressive environment and may be used as a prognostic biomarker and therapeutic target.
人类12号染色体包含IκB激酶相互作用蛋白（IKBIP），也通常被称为IKIP。IKBIP在肿瘤生长中的作用仅在少数出版物中有所讨论。为了探究IKBIP在多种肿瘤发生发展以及肿瘤免疫微环境中所起的作用，利用UALCAN、HPA、基因型组织表达、癌症基因组图谱等数据集来分析IKBIP的表达情况。我们深入研究了IKBIP在泛癌、临床特征和基因异常方面的预测重要性。我们研究了IKBIP与免疫相关基因、微卫星不稳定性（MSI）以及肿瘤突变负担（TMB）发生率之间是否存在联系。利用来自ImmuCellAI、TIMER2以及早期研究的免疫细胞浸润数据，研究了免疫细胞浸润与IKBIP表达之间的联系。最后，进行基因集富集分析（GSEA）以确定与IKBIP相关的信号通路。IKBIP在大多数癌症中高表达，并且与几种主要癌症类型的预后呈负相关。此外，IKBIP的表达在13种癌症中与TMB相关，在7种癌症中与MSI相关。此外，IKBIP与众多免疫和促癌通路相关。同时，不同癌症类型具有独特的肿瘤浸润免疫细胞谱。IKBIP有潜力作为一种泛癌癌基因，对肿瘤发生和癌症免疫都至关重要。IKBIP表达升高意味着免疫抑制环境，可用作预后生物标志物和治疗靶点。
