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泛发性脓疱型银屑病(GPP)临床表现的多样性:来自世界各地的一系列病例简述。

Diversity in the clinical presentation of generalized pustular psoriasis (GPP): A series of case vignettes from around the world.

机构信息

Department of Dermatology, Hospital Sultanah Aminah, and Clinical School Johor Bahru, Monash University Malaysia, Subang Jaya, Malaysia.

University of Alabama School of Medicine, Birmingham, Alabama, USA.

出版信息

Exp Dermatol. 2023 Aug;32(8):1284-1295. doi: 10.1111/exd.14794. Epub 2023 Mar 31.

Abstract

A key principle of clinical studies and case reports is that they should reflect the demographics and epidemiology of the patient population concerned. Here, we have compiled a diverse group of clinical cases of generalized pustular psoriasis (GPP) to showcase the differences in GPP presentation in patients worldwide. We attempt to capture the broad spectrum of clinical presentations of GPP and showcase the diversity of the patient population. The patients included in this series are diverse in age, genetic background, skin phototype and medical history. Moreover, they present with a variety of clinical courses of GPP and different degrees of systemic involvement, and experience flares triggered by different inciting factors. The key learnings from this case series may support physicians in identifying and managing patients with this rare and multifaceted disease that can affect patients both physically and psychologically.

摘要

临床研究和病例报告的一个关键原则是,它们应该反映所关注患者人群的人口统计学和流行病学特征。在这里,我们汇集了一组多样化的泛发性脓疱型银屑病(GPP)临床病例,以展示全球患者中 GPP 表现的差异。我们试图捕捉 GPP 的广泛临床表现,并展示患者人群的多样性。本系列中纳入的患者在年龄、遗传背景、皮肤光型和病史方面存在差异。此外,他们表现出不同的 GPP 临床病程和不同程度的全身受累,并因不同的诱发因素而出现病情加重。从这个病例系列中获得的关键经验可能有助于医生识别和管理患有这种罕见且多方面疾病的患者,这种疾病可能会对患者的身体和心理造成影响。

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