Deng Hui, Ai Meichen, Cao Yuchen, Cai Liyang, Guo Xi, Yang Xiongyi, Yi Guoguo, Fu Min
Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, No. 253, Industrial Avenue Middle, Haizhu, Guangzhou, 510280, Guangdong, China.
The Second Clinical School of Southern Medical University, Guangzhou, 510280, Guangdong, China.
Ophthalmol Ther. 2023 Jun;12(3):1519-1534. doi: 10.1007/s40123-023-00702-3. Epub 2023 Mar 31.
Adiponectin, one of the most ubiquitous adipokines found in the blood, plays a major role in glucolipid metabolism and energy metabolism and regulation. In recent years, a growing body of research indicates that adiponectin also plays a significant role in diabetic retinopathy. In the present review, we specifically address the protective effects of adiponectin on the development and progression of diabetic retinopathy through improvement in insulin resistance, alleviation of oxidative stress, limiting of inflammation, and prevention of vascular remodeling, with the aim to explore new potential approaches and targets for the prevention and treatment of diabetic retinopathy.
脂联素是血液中最常见的脂肪因子之一，在糖脂代谢以及能量代谢与调节中发挥着主要作用。近年来，越来越多的研究表明脂联素在糖尿病视网膜病变中也起着重要作用。在本综述中，我们具体阐述了脂联素通过改善胰岛素抵抗、减轻氧化应激、限制炎症反应以及预防血管重塑，对糖尿病视网膜病变的发生和发展具有保护作用，旨在探索预防和治疗糖尿病视网膜病变的新潜在方法和靶点。
